Frontiers in Immunology | |
After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism | |
Immunology | |
Gary Sisson1  Steven P. Gygi2  Joao A. Paulo2  Christopher Richardson3  Prathyusha Konda4  Vishnupriyan Kumar5  Youra Kim5  Namit Holay5  Michael Giacomantonio5  J. Patrick Murphy6  Tatjana Brauer-Chapin7  Shashi Gujar8  Derek Clements9  Barry E. Kennedy1,10  Mariam Elaghil1,10  | |
[1] Department of Biology, University of Prince Edward Island, Charlottetown, PEI, Canada;Department of Cell Biology, Harvard Medical School, Harvard University, Boston, MA, United States;Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada;Canadian Centre for Vaccinology, IWK Health Centre, Goldbloom Pavilion, Halifax, NS, Canada;Department of Pediatrics, Dalhousie University, Halifax, NS, Canada;Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada;Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, United States;Department of Pathology, Dalhousie University, Halifax, NS, Canada;Department of Pathology, Dalhousie University, Halifax, NS, Canada;Department of Biology, University of Prince Edward Island, Charlottetown, PEI, Canada;Department of Pathology, Dalhousie University, Halifax, NS, Canada;Department of Cell Biology, Harvard Medical School, Harvard University, Boston, MA, United States;Department of Pathology, Dalhousie University, Halifax, NS, Canada;Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada;Department of Biology, Dalhousie University, Halifax, NS, Canada;Beatrice Hunter Cancer Research Institute, Halifax, NS, Canada;Cancer Immunotherapy: Innovation & Global Partnerships, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada;Department of Pathology, Dalhousie University, Halifax, NS, Canada;Department of Microbiology and Immunology, Stanford University, Stanford, CA, United States;Department of Pathology, Dalhousie University, Halifax, NS, Canada;IMV Inc, Halifax, NS, Canada; | |
关键词: antiviral immunity; CD8 T cells; bystander activation; naïve CD8 T cells; type I interferons; immunometabolism; NAD salvage metabolism; metabolic reprogramming; | |
DOI : 10.3389/fimmu.2022.1047661 | |
received in 2022-09-18, accepted in 2022-12-20, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander activation of pre-existing memory CD8 T cells is known to play an important role in host defense and immunopathology, its impact on naïve CD8 T cells remains underappreciated. Here we report that exposure to reovirus, both in vitro or in vivo, promotes bystander activation of naïve CD8 T cells within 24 hours and that this distinct subtype of CD8 T cell displays an innate, antiviral, type I interferon sensitized signature. The induction of bystander naïve CD8 T cells is STAT1 dependent and regulated through nicotinamide phosphoribosyl transferase (NAMPT)-mediated enzymatic actions within NAD+ salvage metabolic biosynthesis. These findings identify a novel aspect of CD8 T cell activation following virus infection with implications for human health and physiology.
【 授权许可】
Unknown
Copyright © 2023 Holay, Kennedy, Murphy, Konda, Giacomantonio, Brauer-Chapin, Paulo, Kumar, Kim, Elaghil, Sisson, Clements, Richardson, Gygi and Gujar
【 预 览 】
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RO202310100801750ZK.pdf | 2200KB | download |