Journal of Leukocyte Biology | |
Immunopathogenesis of atherosclerosis | |
Burkhard Ludewig1  Elke Scandella1  Philippe Krebs1  | |
[1] Research Department, Kantonal Hospital St. Gallen, SwitzerlandResearch Department, Kantonal Hospital St. Gallen, SwitzerlandResearch Department, Kantonal Hospital St. Gallen, Switzerland | |
关键词: immunopathology; bystander activation; molecular mimicry; transgenic mouse model; | |
DOI : 10.1189/jlb.1203605 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
Recent clinical studies indicate that the number of microbial infections (the “pathogen burdenâ€) critically determines the development and progression of atherosclerotic disease. Viruses or bacteria with a specific tropism for cells of the vascular wall may contribute to the initial vascular injury via direct cytopathic effects or via the induction of genuine autoimmune responses. Immunopathological processes such as molecular mimicry, epitope spreading, or bystander activation of self-reactive lymphocytes most likely fuel the chronic inflammatory process in the vascular wall. Recognition of atherogenesis as a pathogen-driven, immunopathological process makes this disease amenable to new treatment strategies such as vaccination or immunomodulation.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010182328ZK.pdf | 41KB | download |