Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI study

Frontiers in Neurology

Neurology

Li Chen¹  Jeffrey Zhongxue Mah²  Yu Hou³  Xiao Liu⁴  Song Wang⁵  Guanhu Yang⁶  Sheng-wang Han⁷  Xiao-ling Li⁸  Dan-na Cao⁸  Yang Wang⁸  Li-na Cai⁹  Xuan Cui⁹  Wei-wei Zhao^1,10  Ang Li^1,11  Qinhong Zhang^1,12  Jinhuan Yue^1,13 

[1] Confucius Institute for TCM, London South Bank University, London, United Kingdom;Department of Acupuncture and Moxibustion, Vitality University, Hayward, CA, United States;Department of Gynecology, Harbin Traditional Chinese Medicine Hospital, Harbin, China;Department of Pediatrics, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China;Department of Radiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Department of Specialty Medicine, Ohio University, Athens, OH, United States;Department of Third Rehabilitation Medicine, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China;Division of CT and MRI, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China;Graduate School of Heilongjiang University of Chinese Medicine, Harbin, China;MSD R&D (China) Co., Ltd., Beijing, China;Sanofi-Aventis China Investment Co., Ltd., Beijing, China;Shenzhen Frontiers in Chinese Medicine Research Co., Ltd., Shenzhen, China;Department of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine, Harbin, China;Shenzhen Frontiers in Chinese Medicine Research Co., Ltd., Shenzhen, China;Department of Acupuncture and Moxibustion, Vitality University, Hayward, CA, United States;

关键词: amnestic mild cognitive impairment;    resting-state functional magnetic resonance imaging;    regional homogeneity;    amplitude of low-frequency fluctuation;    imaging marker;   

DOI  :  10.3389/fneur.2023.1244696

 received in 2023-06-23, accepted in 2023-08-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundAmnestic mild cognitive impairment (aMCI) is an early stage of Alzheimer’s disease (AD). Regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) are employed to explore spontaneous brain function in patients with aMCI. This study applied ALFF and ReHo indicators to analyze the neural mechanism of aMCI by resting-state functional magnetic resonance imaging (rs-fMRI).MethodsTwenty-six patients with aMCI were included and assigned to the aMCI group. The other 26 healthy subjects were included as a healthy control (HC) group. Rs-fMRI was performed for all participants in both groups. Between-group comparisons of demographic data and neuropsychological scores were analyzed using SPSS 25.0. Functional imaging data were analyzed using DPARSF and SPM12 software based on MATLAB 2017a. Gender, age, and years of education were used as covariates to obtain ALFF and ReHo indices.ResultsCompared with HC group, ALFF decreased in the left fusiform gyrus, left superior temporal gyrus, and increased in the left cerebellum 8, left inferior temporal gyrus, left superior frontal gyrus (BA11), and right inferior temporal gyrus (BA20) in the aMCI group (p < 0.05, FWE correction). In addition, ReHo decreased in the right middle temporal gyrus and right anterior cuneiform lobe, while it increased in the left middle temporal gyrus, left inferior temporal gyrus, cerebellar vermis, right parahippocampal gyrus, left caudate nucleus, right thalamus, and left superior frontal gyrus (BA6) (p < 0.05, FWE correction). In the aMCI group, the ALFF of the left superior frontal gyrus was negatively correlated with Montreal Cognitive Assessment (MoCA) score (r = −0.437, p = 0.026), and the ALFF of the left superior temporal gyrus was positively correlated with the MoCA score (r = 0.550, p = 0.004). The ReHo of the right hippocampus was negatively correlated with the Mini-Mental State Examination (MMSE) score (r = −0.434, p = 0.027), and the ReHo of the right middle temporal gyrus was positively correlated with MMSE score (r = 0.392, p = 0.048).ConclusionFunctional changes in multiple brain regions rather than in a single brain region have been observed in patients with aMCI. The abnormal activity of multiple specific brain regions may be a manifestation of impaired central function in patients with aMCI.

【 授权许可】

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Copyright © 2023 Yue, Han, Liu, Wang, Zhao, Cai, Cao, Mah, Hou, Cui, Wang, Chen, Li, Li, Yang and Zhang.