Altered Frequency-Dependent Brain Activation and White Matter Integrity Associated With Cognition in Characterizing Preclinical Alzheimer’s Disease Stages

Frontiers in Human Neuroscience

Wenying Ma¹  Fuquan Zhang²  Xiangrong Zhang²  Yingying Yue³  Chen Xue⁴  Wenzhang Qi⁴  Jiang Rao⁵  Siyu Wang⁶  Jiu Chen⁶  Honglin Ge⁷  Guanjie Hu⁷ 

[1] Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China;Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China;Department of Psychosomatics and Psychiatry, The Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China;Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China;Department of Rehabilitation, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China;Fourth Clinical College of Nanjing Medical University, Nanjing, China;Institute of Brain Functional Imaging, Nanjing Medical University, Nanjing, China;Institute of Neuropsychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Fourth Clinical College of Nanjing Medical University, Nanjing, China;

关键词: amplitude of low-frequency fluctuation;    diffusion tensor imaging;    amnestic mild cognitive impairment;    subjective cognitive decline;    non-amnestic mild cognitive impairment;   

DOI  :  10.3389/fnhum.2021.625232

来源: DOAJ

【 摘 要 】

BackgroundSubjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI) are regarded to be at high risk of converting to Alzheimer’s disease (AD). Amplitude of low-frequency fluctuations (ALFF) can reflect functional deterioration while diffusion tensor imaging (DTI) is capable of detecting white matter integrity. Our study aimed to investigate the structural and functional alterations to further reveal convergence and divergence among SCD, naMCI, and aMCI and how these contribute to cognitive deterioration.MethodsWe analyzed ALFF under slow-4 (0.027–0.073 Hz) and slow-5 (0.01–0.027 Hz) bands and white matter fiber integrity among normal controls (CN), SCD, naMCI, and aMCI groups. Correlation analyses were further utilized among paired DTI alteration, ALFF deterioration, and cognitive decline.ResultsFor ALFF calculation, ascended ALFF values were detected in the lingual gyrus (LING) and superior frontal gyrus (SFG) within SCD and naMCI patients, respectively. Descended ALFF values were presented mainly in the LING, SFG, middle frontal gyrus, and precuneus in aMCI patients compared to CN, SCD, and naMCI groups. For DTI analyses, white matter alterations were detected within the uncinate fasciculus (UF) in aMCI patients and within the superior longitudinal fasciculus (SLF) in naMCI patients. SCD patients presented alterations in both fasciculi. Correlation analyses revealed that the majority of these structural and functional alterations were associated with complicated cognitive decline. Besides, UF alterations were correlated with ALFF deterioration in the SFG within aMCI patients.ConclusionsSCD shares structurally and functionally deteriorative characteristics with aMCI and naMCI, and tends to convert to either of them. Furthermore, abnormalities in white matter fibers may be the structural basis of abnormal brain activation in preclinical AD stages. Combined together, it suggests that structural and functional integration may characterize the preclinical AD progression.

【 授权许可】

Unknown