Extracellular vesicles as a new horizon in the diagnosis and treatment of inflammatory eye diseases: A narrative review of the literature

Frontiers in Immunology

Immunology

Amir Khosravi¹  Mahmood Nejabat¹  Sara Pakbaz²  Masood Soleimani³  Zeinab Zarei-Behjani⁴  Zahra Moayedfard⁴  Azam Habibi⁴  Kimia Falamarzi⁵  Fatemeh Ebrahimi⁵  Mahdi Malekpour⁵  Niloofar Dehdari Ebrahimi⁶  Negar Azarpira⁶ 

[1] Department of Ophthalmology School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;Department of Pathology, University of Toronto, Toronto, ON, Canada;Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran;Department of Tissue Engineering and Cell Therapy, School of Advanced Technologies in Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran;Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;

关键词: inflammation;    autoimmune;    infection;    extracellular vesicles;    exosome;    eye;    mesenchymal stem cells;   

DOI  :  10.3389/fimmu.2023.1097456

 received in 2022-11-13, accepted in 2023-02-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

Extracellular vesicles include exosomes, microvesicles, and apoptotic bodies. Their cargos contain a diverse variety of lipids, proteins, and nucleic acids that are involved in both normal physiology and pathology of the ocular system. Thus, studying extracellular vesicles may lead to a more comprehensive understanding of the pathogenesis, diagnosis, and even potential treatments for various diseases. The roles of extracellular vesicles in inflammatory eye disorders have been widely investigated in recent years. The term “inflammatory eye diseases” refers to a variety of eye conditions such as inflammation-related diseases, degenerative conditions with remarkable inflammatory components, neuropathy, and tumors. This study presents an overview of extracellular vesicles’ and exosomes’ pathogenic, diagnostic, and therapeutic values in inflammatory eye diseases, as well as existing and potential challenges.

【 授权许可】

Unknown   
Copyright © 2023 Habibi, Zarei-Behjani, Falamarzi, Malekpour, Ebrahimi, Soleimani, Nejabat, Khosravi, Moayedfard, Pakbaz, Dehdari Ebrahimi and Azarpira