The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Bao Zhang¹  Yuhao Lin¹  Qiqi Sun¹  Chenguang Shen²  Wei Zhao³ 

[1] BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China;null;[e-mail];

关键词: SARS-CoV-2;    COVID-19;    non-coding RNA;    miRNA;    lncRNA;    mechanism;   

DOI  :  10.3389/fcell.2023.1229393

 received in 2023-05-26, accepted in 2023-07-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

The coronavirus disease 2019 (COVID-19) was a global endemic that continues to cause a large number of severe illnesses and fatalities. There is increasing evidence that non-coding RNAs (ncRNAs) are crucial regulators of viral infection and antiviral immune response and the role of non-coding RNAs in SARS-CoV-2 infection has now become the focus of scholarly inquiry. After SARS-CoV-2 infection, some ncRNAs’ expression levels are regulated to indirectly control the expression of antiviral genes and viral gene replication. However, some other ncRNAs are hijacked by SARS-CoV-2 in order to help the virus evade the immune system by suppressing the expression of type I interferon (IFN-1) and controlling cytokine levels. In this review, we summarize the recent findings of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) among non-coding RNAs in SARS-CoV-2 infection and antiviral response, discuss the potential mechanisms of actions, and prospects for the detection, treatment, prevention and future directions of SARS-CoV-2 infection research.

【 授权许可】

Unknown   
Copyright © 2023 Lin, Sun, Zhang, Zhao and Shen.