Synthesis of efficient cobalt–metal organic framework as reusable nanocatalyst in the synthesis of new 1,4-dihydropyridine derivatives with antioxidant activity

Frontiers in Chemistry

Chemistry

Samar Emad Izzat¹  Omar dheyauldeen Salahdin²  Indrajit Patra³  Ahmed B. Mahdi⁴  Ali Thaeer Hammid⁵  Mohammed Kadhem Abid⁶  Himanshu Sharma⁷  Yasser Fakri Mustafa⁸  Mohammad Javed Ansari⁹  Khusniddin Fakhriddinovich Uktamov^1,10 

[1]Al-Nisour University College, Baghdad, Iraq

[2]Al-maarif University College, Medical Laboratory Techniques Department, Anbar-Ramadi, Iraq

[3]An Independent Researcher, PhD from NIT Durgapur, Durgapur, West Bengal, India

[4]Anesthesia Techniques Department, Al-Mustaqbal University College, Babylon, Iraq

[5]Computer Engineering Techniques Department, Faculty of Information Technology, Imam Ja’afar Al-Sadiq University, Baghdad, Iraq

[6]Department of Anesthesia, College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq

[7]Department of Computer Engineering and Applications, GLA University Mathura, Uttar Pradesh, India

[8]Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

[9]Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj, Saudi Arabia

[10]Senior teacher at “Economic security” Department, Tashkent State University of Economics, Tashkent, Uzbekistan

关键词: cobalt–metal organic framework;    catalytic activity;    dihydropyridine;    antioxidant activity;    DPPH method;   

DOI  :  10.3389/fchem.2022.932902

 received in 2022-05-21, accepted in 2022-07-12,  发布年份 2022

来源: Frontiers

【 摘 要 】

Efficient cobalt–metal organic framework (Co-MOF) was prepared via a controllable microwave-assisted reverse micelle synthesis route. The products were characterized by SEM image, N2 adsorption/desorption isotherm, FTIR spectrum, and TG analysis. Results showed that the products have small particle size distribution, homogenous morphology, significant surface area, and high thermal stability. The physicochemical properties of the final products were remarkable compared with other MOF samples. The newly synthesized nanostructures were used as recyclable catalysts in the synthesis of 1,4-dihydropyridine derivatives. After the confirmation of related structures, the antioxidant activity of derivatives based on the DPPH method was evaluated and the relationship between structures and antioxidant activity was observed. In addition to recyclability, the catalytic activity of Co-MOF studied in this research has remarkable effects on the synthesis of 1,4 dihydropyridine derivatives.

【 授权许可】

Unknown   
Copyright © 2022 Salahdin, Patra, Ansari, Emad Izzat, Uktamov, Abid, Mahdi, Hammid, Mustafa and Sharma.

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