期刊论文详细信息
Molecules | |
N-Methyl-(R)-3-(tert-Butyl)-Sulfinyl-1,4-Dihydropyridine: A Novel NADH Model Compound | |
Kun Xie1  You-Cheng Liu1  Yi Cui1  Jian-Ge Wang1  Yao Fu1  | |
[1] 1Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China | |
关键词: NADH model compound; chiral; sulfoxide; dihydropyridine; synthesis; | |
DOI : 10.3390/12030415 | |
来源: mdpi | |
【 摘 要 】
We have synthesized a novel chiral NADH model compound, N-methyl-(R)-3-(tert-butyl)-sulphinyl-1,4-dihydropyridine with high enantioselectivity and used it in the reduction of methyl benzoylformate, producing (S)-methyl mandelate in 95% ee. The absolute structure of its precursor, 3-(tert-butyl)sulfinyl pyridine, was determined by X-ray analysis.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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