N-Methyl-(R)-3-(tert-Butyl)-Sulfinyl-1,4-Dihydropyridine: A Novel NADH Model Compound

Molecules

Kun Xie¹  You-Cheng Liu¹  Yi Cui¹  Jian-Ge Wang¹  Yao Fu¹ 

[1] ¹Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China

关键词: NADH model compound;    chiral;    sulfoxide;    dihydropyridine;    synthesis;   

DOI  :  10.3390/12030415

来源: mdpi

【 摘 要 】

We have synthesized a novel chiral NADH model compound, N-methyl-(R)-3-(tert-butyl)-sulphinyl-1,4-dihydropyridine with high enantioselectivity and used it in the reduction of methyl benzoylformate, producing (S)-methyl mandelate in 95% ee. The absolute structure of its precursor, 3-(tert-butyl)sulfinyl pyridine, was determined by X-ray analysis.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.