期刊论文详细信息
Molecules | |
N-Methyl-(R)-3-(tert-Butyl)-Sulfinyl-1,4-Dihydropyridine: A Novel NADH Model Compound | |
关键词: NADH model compound; chiral; sulfoxide; dihydropyridine; synthesis; | |
DOI : 10.3390/12030415 | |
来源: DOAJ |
【 摘 要 】
We have synthesized a novel chiral NADH model compound, N-methyl-(R)-3-(tert-butyl)-sulphinyl-1,4-dihydropyridine with high enantioselectivity and used it in the reduction of methyl benzoylformate, producing (S)-methyl mandelate in 95% ee. The absolute structure of its precursor, 3-(tert-butyl)sulfinyl pyridine, was determined by X-ray analysis.
【 授权许可】
Unknown