Exosomes may be the carrier of acupuncture treatment for major depressive disorder

Frontiers in Behavioral Neuroscience

Neuroscience

Mei Lu¹  Xin Zhou¹  Hai-Yang Chen¹  Lu Ren²  Liu-Qing Shi²  Qin Lyu²  Xian-De Ma³ 

[1] Department of Acupuncture and Moxibustion, Liaoning University of Traditional Chinese Medicine, Shenyang, China;Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang, China;Teaching and Experiment Center, Liaoning University of Traditional Chinese Medicine, Shenyang, China;

关键词: acupuncture;    exosomes;    major depressive disorder;    Traditional Chinese Medicine (TCM);    alternative therapies;    opportunity;    mechanism;    antidepressant;   

DOI  :  10.3389/fnbeh.2023.1107265

 received in 2022-11-24, accepted in 2023-02-01,  发布年份 2023

来源: Frontiers

【 摘 要 】

The incidence of major depressive disorder (MDD) is increasing all over the world. There is a great need for complementary or alternative therapies with high safety, few side effects, and precise efficacy to care for MDD. In China, acupuncture has significant laboratory data and clinical trials to demonstrate its antidepressant efficacy. However, there is no clear answer as to how it works. Exosomes are membranous vesicles that rely on cellular multivesicular bodies (MVBs) fused to the cell membrane for release into the extracellular matrix. Almost all cell types are capable of producing and releasing exosomes. As a result, exosomes contain complex RNAs and proteins from their relatives (Cells that secretes exosomes). They can cross biological barriers and participate in biological activities, such as cell migration, angiogenesis, and immune regulation. These properties have made them a popular research topic. Some experts have suggested that exosomes may serve as delivery vehicles for acupuncture to work. This presents both an opportunity and a new challenge for improving the protocols of acupuncture as a treatment for MDD. To better define the relationship between MDD, exosomes, and acupuncture, we reviewed the literature from the last few years. Inclusion criteria included randomized controlled trials and basic trials evaluating acupuncture in the treatment or prevention of MDD, the role of exosomes in the development and progression of MDD, and the role of exosomes in acupuncture. We believe that acupuncture may affect the distribution of exosomes in vivo, and exosomes may be a new carrier for acupuncture treatment of MDD in the future.

【 授权许可】

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Copyright © 2023 Lyu, Zhou, Shi, Chen, Lu, Ma and Ren.