Association between gut microbiota and psychiatric disorders: a systematic review

Frontiers in Psychology

Psychology

Carmen Grau-Del Valle¹  Javier Fernández¹  Celia Bañuls¹  Carlos Morillas²  Eva Solá²  Inmaculada Montoya-Castilla³ 

[1] Department of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain;Department of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain;Department of Medicine, University of Valencia, Valencia, Spain;Department of Personality, Assessment and Psychological Treatment, University of Valencia, Valencia, Spain;

关键词: gut microbiota;    psychiatric disorders;    human;    dysbiosis;    gut-brain axis;   

DOI  :  10.3389/fpsyg.2023.1215674

 received in 2023-05-02, accepted in 2023-07-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionIn recent years, it has been described that the dysbiosis of the intestinal microbiota plays a transcendental role in several pathologies. In this sense, the importance of the gut microbiota in the gut-brain axis, with a bidirectional communication, has been demonstrated. Furthermore, the gut microbiota has been linked with mood disorders and neuropsychiatric disorders.MethodsA systematic review of two databases – PubMed and Scopus – was carried out following PRISMA guidelines. We included original studies in humans with a control group published in the last 11 years, which were assessed by the Critical Appraisal Skills Program (CASP) to confirm their quality. Eighteen articles met all the selection criteria.ResultsA review of the articles revealed an association between psychiatric disorders and different bacterial phyla. The studies we have reviewed have demonstrated differences between subjects with psychiatric disorders and controls and highlight a clear relationship between depression, stress, autism spectrum disorder (ASD), psychotic episodes, eating disorders, anxiety and brain function and the gut microbiota composition.ConclusionA reduction of fermentative taxa has been observed in different psychiatric disorders, resulting in a decrease in the production of short-chain fatty acids (SCFAs) and an increase in pro-inflammatory taxa, both of which may be consequences of the exacerbation of these pathologies.

【 授权许可】

Unknown   
Copyright © 2023 Grau-Del Valle, Fernández, Solá, Montoya-Castilla, Morillas and Bañuls.