The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Lei Song¹  Yuhao Zhou¹  Shucheng Hua¹ 

[1] Department of Respiratory Medicine, Center for Pathogen Biology and Infectious Diseases, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China;State Key Laboratory for Zoonotic Diseases, The First Hospital of Jilin University, Changchun, China;

关键词: intracellular bacterial infection;    p62 (sequestosome 1(SQSTM1);    xenophagy;    bacterial protein;    microdomain;   

DOI  :  10.3389/fcimb.2023.1180708

 received in 2023-03-06, accepted in 2023-04-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy. Recent research has shown that p62 is crucial in eradicating intracellular bacteria by xenophagy, a selective autophagic process that identifies and eliminates such microorganisms. This review highlights the various roles of p62 in intracellular bacterial infections, including both direct and indirect, antibacterial and infection-promoting aspects, and xenophagy-dependent and independent functions, as documented in published literature. Additionally, the potential applications of synthetic drugs targeting the p62-mediated xenophagy mechanism and unresolved questions about p62’s roles in bacterial infections are also discussed.

【 授权许可】

Unknown   
Copyright © 2023 Zhou, Hua and Song