Structural and functional changes of the cerebellum in temporal lobe epilepsy

Frontiers in Neurology

Neurology

Lily Wan¹  Wenyue Wu²  Haiting Zhao³  Min Zhang³  Lili Long³  Kangrun Wang³  Ge Wang³  Xianghe Liu³  Chaorong Liu³  Bo Xiao³  Yayu Chen⁴ 

[1] Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China;Department of Neurology, Xiangya Hospital, Central South University, Changsha, China;Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China;Department of Neurology, Xiangya Hospital, Central South University, Changsha, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China;Department of Neurology, Xiangya Hospital, Central South University, Changsha, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, China;

关键词: cerebellar peduncle;    cerebellum;    functional connectivity;    multimodality MRI;    temporal lobe epilepsy;   

DOI  :  10.3389/fneur.2023.1213224

 received in 2023-04-27, accepted in 2023-07-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

AimsThis study aimed to comprehensively explore the cerebellar structural and functional changes in temporal lobe epilepsy (TLE) and its association with clinical information.MethodsThe SUIT toolbox was utilized to perform cerebellar volume and diffusion analysis. In addition, we extracted the average diffusion values of cerebellar peduncle tracts to investigate microstructure alterations. Seed-based whole-brain analysis was used to investigate cerebellar–cerebral functional connectivity (FC). Subgroup analyses were performed to identify the cerebellar participation in TLE with/without hippocampal sclerosis (HS)/focal-to-bilateral tonic–clonic seizure (FBTCS) and TLE with different lateralization.ResultsTLE showed widespread gray matter atrophy in bilateral crusII, VIIb, VIIIb, left crusI, and left VIIIa. Both voxel and tract analysis observed diffusion abnormalities in cerebellar afferent peduncles. Reduced FC between the right crus II and the left parahippocampal cortex was found in TLE. Additionally, TLE showed increased FCs between left lobules VI–VIII and cortical nodes of the dorsal attention and visual networks. Across all patients, decreased FC was associated with poorer cognitive function, while increased FCs appeared to reflect compensatory effects. The cerebellar structural changes were mainly observed in HS and FBTCS subgroups and were regardless of seizure lateralization, while cerebellar–cerebral FC alterations were similar in all subgroups.ConclusionTLE exhibited microstructural changes in the cerebellum, mainly related to HS and FBTCS. In addition, altered cerebellar–cerebral functional connectivity is associated with common cognitive alterations in TLE.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Liu, Zhang, Wang, Liu, Chen, Wu, Zhao, Xiao, Wan and Long.