GDF10 is related to obesity as an adipokine derived from subcutaneous adipose tissue

Frontiers in Endocrinology

Endocrinology

Sun Jong Han¹  Seok Hwan Kim¹  Mi Kyung Song²  Hyun Jin Kim³  Bon Jeong Ku³  Ju Hee Lee³  Yea Eun Kang³  Ji Eun Kim⁴  Jung Tae Kim⁴ 

[1] Department of General Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea;Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea;Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea;Research Center for Endocrine and Metabolic Disease, Chungnam National University College of Medicine, Daejeon, Republic of Korea;Research Center for Endocrine and Metabolic Disease, Chungnam National University College of Medicine, Daejeon, Republic of Korea;

关键词: GDF10;    subcutaneous fat;    adipokines;    obesity;    adipose tissue;   

DOI  :  10.3389/fendo.2023.1159515

 received in 2023-02-06, accepted in 2023-05-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionAdipokines are proteins that are secreted by the adipose tissue. Although they are associated with obesity-related metabolic disorders, most studies have focused on adipokines expressed by visceral adipose tissue (VAT). This study aimed to identify the adipokine potentially derived from subcutaneous adipose tissue (SAT) and its clinical significance.MethodsSamples of SAT and VAT were obtained from six adult male patients who underwent laparoscopic surgery for benign gall bladder disease. Differentially expressed genes were analyzed by subjecting the samples to RNA sequencing. The serum concentration of selected proteins according to body mass index (BMI) was analyzed in 58 individuals.ResultsGDF10 showed significantly higher expression in the SAT, as per RNA sequencing (fold change = 5.8, adjusted P value = 0.009). Genes related to insulin response, glucose homeostasis, lipid homeostasis, and fatty acid metabolism were suppressed when GDF10 expression was high in SAT, as per genotype-tissue expression data. The serum GDF10 concentration was higher in participants with BMI ≥ 25 kg/m2 (n = 35, 2674 ± 441 pg/mL) than in those with BMI < 25 kg/m2 (n = 23, 2339 ± 639 pg/mL; P = 0.022). There was a positive correlation between BMI and serum GDF10 concentration (r = 0.308, P = 0.019).ConclusionsGDF10 expression was higher in SAT than in VAT. Serum GDF10 concentration was high in patients with obesity. Therefore, GDF10 could be a SAT-derived protein related to obesity.

【 授权许可】

Unknown   
Copyright © 2023 Song, Kim, Kim, Kang, Han, Kim, Kim, Ku and Lee