Impact of Body Composition on the Risk of Hepatocellular Carcinoma Recurrence After Liver Transplantation

Journal of Clinical Medicine

Marek Krawczyk¹  Michał Grąt¹  Krzysztof Zieniewicz¹  Karolina Grąt²  Ryszard Pacho²  Olgierd Rowiński² 

[1] Department of General, Transplant and Liver Surgery, Medical University of Warsaw, 02-097 Warsaw, Poland;Second Department of Clinical Radiology, Medical University of Warsaw, 02-097 Warsaw, Poland;

关键词: obesity;    hepatocellular carcinoma;    liver transplantation;    subcutaneous fat;    visceral fat;    computed tomography;    adipose tissue;    sarcopenia;   

DOI  :  10.3390/jcm8101672

来源: DOAJ

【 摘 要 】

Background: Body composition parameters are reported to influence the risk of hepatocellular carcinoma (HCC) recurrence after liver resection, yet data on patients undergoing liver transplantation are scarce. The aim of this study was to evaluate the impact of the amount of abdominal adipose tissue and skeletal muscles on the risk of HCC recurrence after liver transplantation. Methods: This was a retrospective observational study performed on 77 HCC patients after liver transplantation. Subcutaneous fat area (SFA), visceral fat area, psoas muscle area and total skeletal muscle area were assessed on computed tomography on the level of L3 vertebra and divided by square meters of patient height. The primary outcome measure was five-year recurrence-free survival. Results: Recurrence-free survival in the entire cohort was 95.7%, 90.8%, and 86.5% after one, three, and five years post-transplantation, respectively. SFA was significantly associated with the risk of HCC recurrence (p = 0.013), whereas no significant effects were found for visceral fat and skeletal muscle indices. The optimal cut-off for SFA for prediction of recurrence was 71.5 cm²/m². Patients with SFA < 71.5 cm²/m² and ≥71.5 cm²/m² exhibited five-year recurrence-free survival of 96.0% and 55.4%, respectively (p = 0.001). Conclusions: Excessive amount of subcutaneous adipose tissue is a risk factor for HCC recurrence after liver transplantation and may be considered in patient selection process.

【 授权许可】

Unknown