Insulin and the sebaceous gland function

Frontiers in Physiology

Physiology

Obumneme Emeka Okoro¹  Emanuela Camera²  Enrica Flori²  Monica Ottaviani² 

[1] Dermatology Unit, Federal Medical Centre, Keffi, Nasarawa State, Nigeria;Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, Rome, Italy;

关键词: insulin;    sebaceous gland;    sebocytes;    MTOR signaling;    acne;   

DOI  :  10.3389/fphys.2023.1252972

 received in 2023-07-04, accepted in 2023-08-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Insulin affects metabolic processes in different organs, including the skin. The sebaceous gland (SG) is an important appendage in the skin, which responds to insulin-mediated signals, either directly or through the insulin growth factor 1 (IGF-1) axis. Insulin cues are differently translated into the activation of metabolic processes depending on several factors, including glucose levels, receptor sensitivity, and sebocyte differentiation. The effects of diet on both the physiological function and pathological conditions of the SG have been linked to pathways activated by insulin and IGF-1. Experimental evidence and theoretical speculations support the association of insulin resistance with acne vulgaris, which is a major disorder of the SG. In this review, we examined the effects of insulin on the SG function and their implications in the pathogenesis of acne.

【 授权许可】

Unknown   
Copyright © 2023 Okoro, Camera, Flori and Ottaviani.