Effect of a 3-month L-carnitine supplementation and resistance training program on circulating markers and bone mineral density in postmenopausal women: a randomized controlled trial

Nutrition & Metabolism

Research

Piotr Wisniewski¹  Robert A. Olek²  Jacek Zielinski²  Krystian Wochna³  Pawel Wojtkiewicz⁴  Emilia Samborowska⁵ 

[1] Chair and Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland;Department of Athletics, Strength, and Conditioning, Poznan University of Physical Education, Krolowej Jadwigi 27/39, 61-871, Poznan, Poland;Department of Swimming and Water Lifesaving, Poznan University of Physical Education, Poznan, Poland;Endoscopy and Metabolic Disorders, Seventh Navy Hospital, Gdansk, Poland;Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland;

关键词: Osteonectin;    SPARC;    Decorin;    Trimethylamine N-oxide;    Osteopontin;    Sclerostin;   

DOI  :  10.1186/s12986-023-00752-1

 received in 2022-08-28, accepted in 2023-07-26,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundHigher circulating levels of trimethylamine N-oxide (TMAO), which is a metabolite that can be produced by the gut microbiota from L-carnitine (LC), have been associated with bone mineral density (BMD). Because LC supplementation can improve bone density and microstructural properties in animal models, this study aimed to examine the effects of 12 weeks of LC supplementation on BMD and selected blood markers involved in bone metabolism of postmenopausal women participating in a resistance training (RT) program.MethodsTwenty-seven postmenopausal women, who had not been treated for osteoporosis, with a total T-score above − 3.0 and no diet differences completed 12 weeks of RT. The participants’ diets were supplemented with either 1 g of LC-L-tartrate and 3 g of leucine per day (LC group) or 4 g of leucine per day as a placebo (PLA group), in a double-blind fashion.ResultsAfter the intervention in the LC group, plasma total carnitine and serum decorin levels were higher than the corresponding preintervention values (p = 0.040 and p = 0.042, respectively). Moreover, plasma TMAO and serum SPARC levels were higher in the LC group than the corresponding postintervention values in the PLA group (p < 0.001 and p = 0.030, respectively). No changes in the BMD were observed after 3 months of the intervention.ConclusionsTwelve weeks of LC supplementation during RT program increased plasma TMAO levels and appeared to affect signaling molecules, as indicated by the increase in the resting SPARC and decorin levels, with no significant modification in the BMD.Trial registrationRetrospectively registered at the ClinicalTrials.gov (NCT05120011).

【 授权许可】

CC BY   
© The Author(s) 2023

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