Neural stem cell-derived exosomes and regeneration: cell-free therapeutic strategies for traumatic brain injury

Stem Cell Research & Therapy

Review

Xu Cheng¹  Peng Wang²  Lin Zhong³  Lujia Cao³  Hongwei Wu³  Xiaoyin Liu⁴  Peng Liu⁴  Jing Chen⁴  Liangxue Zhou⁴  Jingjing Wang⁵ 

[1] Department of Anesthesiology, West China Hospital, Sichuan University, 610064, Chengdu, Sichuan, China;Department of Health Management, Tianjin Hospital, 300211, Tianjin, China;Department of Hematology, The First Affiliated Hospital of Chengdu Medical College, 610500, Chengdu, Sichuan, China;Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, 610041, Chengdu, Sichuan, China;Tianjin Key Laboratory of Neurotrauma Repair, Institute of Neurotrauma Repair, Characteristic Medical Center of People’s Armed Police Forces, 300162, Tianjin, China;

关键词: Neural stem cell;    Exosomes;    Traumatic brain injury;    Neuroregeneration;    Neuroinflammation;   

DOI  :  10.1186/s13287-023-03409-1

 received in 2023-01-18, accepted in 2023-07-06,  发布年份 2023

来源: Springer

【 摘 要 】

Regenerative repair of the brain after traumatic brain injury (TBI) remains an extensive clinical challenge, inspiring intensified interest in therapeutic approaches to explore superior repair strategies. Exosome therapy is another research hotspot following stem cell alternative therapy. Prior research verified that exosomes produced by neural stem cells can participate in the physiological and pathological changes associated with TBI and have potential neuroregulatory and repair functions. In comparison with their parental stem cells, exosomes have superior stability and immune tolerance and lower tumorigenic risk. In addition, they can readily penetrate the blood‒brain barrier, which makes their treatment efficiency superior to that of transplanted stem cells. Exosomes secreted by neural stem cells present a promising strategy for the development of novel regenerative therapies. Their tissue regeneration and immunomodulatory potential have made them encouraging candidates for TBI repair. The present review addresses the challenges, applications and potential mechanisms of neural stem cell exosomes in regenerating damaged brains.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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