Two pyrrole acids isolated from Phyllanthus emblica L. and their bioactivities

Natural Products and Bioprospecting

Original Article

Qing-Xia Xu¹  Jun Zhang¹  An Liu¹  Sha Chen¹  Chang Chen¹  Cong Guo¹  Shu-Hui Wang¹  Wen-Jin Cui¹  Jin-Zhu Jiang¹  Yan Liu¹  Jin-Tang Cheng¹ 

[1] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 100700, Beijing, China;

关键词: Pyrrole acid;    Phyllanthus emblica;    Lipid deposition;    ATP-binding cassette transporter A1;    RAW264.7 macrophages;   

DOI  :  10.1007/s13659-023-00393-0

 received in 2023-06-22, accepted in 2023-08-21,  发布年份 2023

来源: Springer

【 摘 要 】

An undescribed pyrrole acid, 1-(4′-methoxy-4′-oxobutyl)-1 H-pyrrole-2,5-dicarboxylic acid (1) and one known pyrrole acid (2) were isolated from the fruits of Phyllanthus emblica. The structures of these compounds were elucidated via the comprehensive analyses of IR, HRESIMS, 1D and 2D spectroscopic data. A series of biological assays revealed that compounds 1 and 2 could inhibit LPS-induced over-production of nitric oxide (NO), interleukin-6 (IL-6), monocyte chemotactic protein 1 (MCP-1) and tumor necrosis factor-α (TNF-α) by reducing the phosphorylation of extracellular regulated protein kinases (ERK) and c-Jun N-terminal kinases (JNK) in RAW 264.7 cells. Additionally, compounds 1 and 2 were found to reduce lipid deposition and increase the mRNA expression of ATP-binding cassette transporter A1 in oxidized low-density lipoprotein-treated RAW264.7 macrophages.Graphical abstract

【 授权许可】

CC BY   
© Kunming Institute of Botany, CAS 2023

【 图 表 】

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