Combined influence of depression and low-grade inflammation on mortality in peritoneal dialysis patients

BMC Nephrology

Research

Xianfeng Wu¹  Yanxia Zhang²  Jiexin Chen²  Ruiying Tang²  Jihong Deng²  Huankai Guo²  Qingdong Xu² 

[1]Department of Nephrology, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, China

[2]Department of Nephrology, Jiangmen Central Hospital, Jiangmen, China

关键词: Depression;    Low-grade inflammation;    Peritoneal dialysis;    Mortality;   

DOI  :  10.1186/s12882-023-03291-2

 received in 2023-05-22, accepted in 2023-08-06,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe relationship between depression and systemic inflammation as risk factors for mortality is not well understood and requires further investigation.MethodsPatients undergoing continuous ambulatory peritoneal dialysis (CAPD) between July 01, 2015 to December 31, 2019, were analyzed and followed up until December 31, 2020. According to their status of depression (PHQ-9 score ≥ 5) and low-grade inflammation (hs-CRP level ≥ 3 mg/L), patients were divided into four groups (G1, without depression, nor inflammation; G2, with depression, without inflammation; G3, with inflammation, without depression; G4, with both depression and inflammation). We performed Kaplan–Meier and multivariable Cox proportional analyses of mortality for the combined influence of depression and systemic inflammation in this cohort.ResultsDuring the mean follow-up of 36.3 ± 14.8 months, 73 deaths were recorded in 358 participants. Compared with patients in group G1, patients in group G2 and G3 carried 137% {hazard ratio (HR): 2.37, 95% confidence interval (CI): 1.06—5.23, p = 0.035} and 140% (HR: 2.40, 95% CI: 1.01—5.69, p = 0.048) higher risk of mortality. Patients in group G4 (with both depression and inflammation) showed the highest risks of all-cause mortality with 276% higher mortality risk (HR: 3.76, 95% CI: 1.73—8.15, p = 0.001), respectively.ConclusionThe combined of depression and inflammation is associated with all-cause mortality in peritoneal dialysis patients, suggesting a need for further study of depression and low-grade inflammation in PD patients and potential relationship between them.

【 授权许可】

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© BioMed Central Ltd., part of Springer Nature 2023