Comparison of sound touch elastography and quantification for assessing the renal pathologic changes in patients with proteinuria

Insights into Imaging

Original Article

Tao Wu¹  Yu Liang²  Liang Hou²  Zhengmin Ruan²  Xue Shi²  Mei Wu²  Zhiying Xiao³ 

[1] Department of Nephrology, The Second Hospital of Shandong University, Jinan, Shandong, China;Department of Ultrasound, The Second Hospital of Shandong University, No 247, Beiyuan Street, 250033, Jinan, Shandong, China;Department of Urology, The Second Hospital of Shandong University, Jinan, Shandong, China;

关键词: Sound touch elastography;    Sound touch quantification;    Shear wave;    Ultrasonography;    Chronic kidney disease;   

DOI  :  10.1186/s13244-023-01476-9

 received in 2023-03-23, accepted in 2023-07-03,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveSound touch elastography (STE) and sound touch quantification (STQ) are novel imaging methods to evaluate tissue stiffness. This study aims to investigate renal stiffness in patients with chronic kidney disease (CKD) by STE and STQ, using renal biopsy as ‘gold standard’.MethodsBetween 2019 January and 2022 June, 60 patients who underwent renal biopsy for proteinuria (cases) and 45 healthy volunteers (controls) at our hospital were included in this study. The maximum and mean elastic modulus (Emax, Emean) of region of interest in right kidney were measured by STE and STQ techniques. Biochemical profiles and renal biopsy findings were recorded.ResultsBoth Emax and Emean measured by STE were significantly different between cases and controls. ROC analysis of STE measurements revealed using a cutoff of 13.53 kPa for Emax and 10.16 kPa for Emean, the area under the curve (AUC) to distinguish nephropathy from healthy was 0.718 and 0.744. Analysis of ROC for STQ measurements showed that using a cutoff value of 15.87 kPa for Emax and 9.95 kPa for Emean, the AUC for the nephropathy was 0.612 and 0.569. Emax and Emean values were significantly different among CKD patients with mild, moderate and severe pathological stage. The Emax value for STE was positively related to Scr, β2-MG (r = 0.257, 0.292, p < 0.05).ConclusionBoth STE and STQ are non-invasive, feasible methods to quantitatively evaluate renal stiffness. STE is more effective than STQ in the diagnosis of CKD patients with proteinuria.Critical relevance statementSound touch elastography is more effective than sound touch quantification in the diagnosis of chronic kidney disease patients with proteinuria.Key points• Emax and Emean measured by STE were different between cases and controls.• Emax and Emean were different among CKD patients with different pathological stages.• The Emax value for STE was positively related to serum creatinine, β2-microglobulinGraphical Abstract

【 授权许可】

CC BY   
© European Society of Radiology (ESR) 2023

【 图 表 】

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