Positive associations between sex hormones, bone metabolism and cognitive impairment in Chinese oldest-old females

BMC Psychiatry

Research

Yali Zhao¹  Chaoxue Ning¹  Long Feng²  Shihui Fu³  Lihua Bian⁴  Ping Ping⁵  Zhitao Gao⁶  Pei Zhang⁷ 

[1] Central Laboratory, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, China;Department of Anesthesia, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, China;Department of Cardiology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, China;Department of Geriatric Cardiology, Chinese People’s Liberation Army General Hospital, Beijing, China;Department of Obstetrics and Gynecology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, China;General Station for Drug and Instrument Supervision and Control, Joint Logistic Support Force of Chinese People’s Liberation Army, Beijing, China;School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China;School of Life Science, Beijing Institute of Technology, Beijing, China;

关键词: Bone metabolism;    Cognitive impairment;    Oldest-old females;    Sex hormones;   

DOI  :  10.1186/s12888-023-04957-9

 received in 2022-12-08, accepted in 2023-06-13,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeWith a rapid increase in older adults, progressive impairment in cognitive function has become an increasing concern owing to high social and economic burdens. The current study was designed to investigate the associations of sex hormones and bone metabolism with cognitive impairment (CI) in Chinese oldest-old females.MethodsThere were 396 oldest-old females from the China Hainan Oldest-old Cohort Study (CHOCS). Following standardized procedures, Mini Mental State Examination was effectively completed, and sex hormones and bone metabolism were assessed in these females.ResultsThe median age of all females was 101 years (range: from 80 to 116). There were 340 females (86%) with CI. Participants with CI had significantly higher levels of age, progesterone, prolactin and estradiol than those without CI (P < 0.05 for all). Total type I collagen N-terminal elongation peptide [hazard ratio (HR): 1.018, 95%CI: 1.001–1.035] and prolactin (HR: 1.065, 95%CI: 1.005–1.129) levels were positively and significantly associated with CI (P < 0.05 for all).ConclusionsProlactin and total type I collagen N-terminal elongation peptide had positive associations with CI in Chinese oldest-old females. Thus, a balance in sex hormones and bone metabolism may have significant effects on cognitive function during the aging process.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023