Environmental exposures in early-life and general health in childhood

Environmental Health

Research

Tiffany Yang¹  John Wright¹  Rosemary McEachan¹  Audrius Dedele²  Regina Grazuleviciene²  Marina Vafeiadi³  Berit Granum⁴  Line Småstuen Haug⁴  Nikos Stratakis⁵  Mónica López-Vicente⁵  Augusto Anguita-Ruiz⁶  Jordi Julvez⁷  Judith Garcia-Aymerich⁸  Léa Maitre⁸  Mark Nieuwenhuijsen⁸  Martine Vrijheid⁸  Maribel Casas⁸  Xavier Basagaña⁸  Montserrat de Castro⁹  Ines Amine^1,10  Alicia Guillien^1,10  Rémy Slama^1,10  Claire Philippat^1,10  Valérie Siroux^1,10  Barbara Heude^1,11  Wen Lun Yuan^1,12 

[1]Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK

[2]Department of Environmental Science, Vytautas Magnus University, 44248, Kaunas, Lithuania

[3]Department of Social Medicine, School of Medicine, University of Crete, Heraklion, Crete, Greece

[4]Division for Climate and Environmental Health, Norwegian Institute of Public Health, 0213, Oslo, Norway

[5]Parc de Recerca Biomèdica de Barcelona (PRBB), ISGlobal-Instituto de Salud Global de Barcelona Campus MAR, 08003, Barcelona, Spain

[6]Parc de Recerca Biomèdica de Barcelona (PRBB), ISGlobal-Instituto de Salud Global de Barcelona Campus MAR, 08003, Barcelona, Spain

[7]CIBEROBN, (Physiopathology of Obesity and Nutrition CB12/03/30038), Institute of Health Carlos III (ISCIII), 28029, Madrid, Spain

[8]Parc de Recerca Biomèdica de Barcelona (PRBB), ISGlobal-Instituto de Salud Global de Barcelona Campus MAR, 08003, Barcelona, Spain

[9]Clinical and Epidemiological Neuroscience (NeuroÈpia), Institut d’Investigació Sanitària Pere Virgili (IISPV), 43204, Reus, Spain

[10]Parc de Recerca Biomèdica de Barcelona (PRBB), ISGlobal-Instituto de Salud Global de Barcelona Campus MAR, 08003, Barcelona, Spain

[11]Pompeu Fabra University (UPF), 08002, Barcelona, Spain

[12]Spanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain

[13]Parc de Recerca Biomèdica de Barcelona (PRBB), ISGlobal-Instituto de Salud Global de Barcelona Campus MAR, 08003, Barcelona, Spain

[14]Pompeu Fabra University (UPF), 08002, Barcelona, Spain

[15]Spanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029, Madrid, Spain

[16]Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain

[17]University Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology applied to Development and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France

[18]Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), 75004, Paris, France

[19]Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), 75004, Paris, France

[20]Singapore Institute for Clinical Science, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

关键词: Environment;    Exposome;    Cohort studies;    Cardiometabolic risk factors;    Neurodevelopment;    Respiratory diseases;    Pregnancy;    Child;    Multimorbidity;    General health status;   

DOI  :  10.1186/s12940-023-01001-x

 received in 2023-02-28, accepted in 2023-06-28,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundEarly-life environmental exposures are suspected to be involved in the development of chronic diseases later in life. Most studies conducted so far considered single or few exposures and single-health parameter. Our study aimed to identify a childhood general health score and assess its association with a wide range of pre- and post-natal environmental exposures.MethodsThe analysis is based on 870 children (6–12 years) from six European birth cohorts participating in the Human Early-Life Exposome project. A total of 53 prenatal and 105 childhood environmental factors were considered, including lifestyle, social, urban and chemical exposures. We built a general health score by averaging three sub-scores (cardiometabolic, respiratory/allergy and mental) built from 15 health parameters. By construct, a child with a low score has a low general health status. Penalized multivariable regression through Least Absolute Shrinkage and Selection Operator (LASSO) was fitted in order to identify exposures associated with the general health score.FindingsThe results of LASSO show that a lower general health score was associated with maternal passive and active smoking during pregnancy and postnatal exposure to methylparaben, copper, indoor air pollutants, high intake of caffeinated drinks and few contacts with friends and family. Higher child’s general health score was associated with prenatal exposure to a bluespace near residency and postnatal exposures to pets, cobalt, high intakes of vegetables and more physical activity. Against our hypotheses, postnatal exposure to organochlorine compounds and perfluorooctanoate were associated with a higher child’s general health score.ConclusionBy using a general health score summarizing the child cardiometabolic, respiratory/allergy and mental health, this study reinforced previously suspected environmental factors associated with various child health parameters (e.g. tobacco, air pollutants) and identified new factors (e.g. pets, bluespace) warranting further investigations.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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