Early Vascular Ageing in adolescents with migraine with aura: a community-based study

BMC Cardiovascular Disorders

Research

Raimund Pechlaner¹  Katharina Kaltseis¹  Gregor Broessner¹  Michael Knoflach²  Stefan Kiechl²  Sophia Julia J. Kiechl³  Benoît Bernar⁴  Christoph Hochmayr⁵  Nina Gande⁵  Ursula Kiechl-Kohlendorfer⁵  Anna Staudt⁵  Bernhard Winder⁶  Anna Katharina Stock⁷  Ralf Geiger⁸ 

[1]Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria

[2]Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria

[3]VASCage, Research Centre on Vascular Ageing and Stroke, Innsbruck, Austria

[4]Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria

[5]VASCage, Research Centre on Vascular Ageing and Stroke, Innsbruck, Austria

[6]Department of Neurology, Hochzirl-Natters Hospital, Zirl, Austria

[7]Department of Pediatrics, Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria

[8]Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria

[9]Department of Pediatrics, Pediatrics II, Medical University of Innsbruck, Innsbruck, Austria

[10]Department of Pediatrics, Pediatrics II, Medical University of Innsbruck, Innsbruck, Austria

[11]Academic Teaching Hospital, Landeskrankenhaus Feldkirch, Feldkirch, Austria

[12]VASCage, Research Centre on Vascular Ageing and Stroke, Innsbruck, Austria

[13]Department of Pediatrics, Pediatrics II, Medical University of Innsbruck, Innsbruck, Austria

[14]Department of Pediatrics, Pediatrics III, Medical University of Innsbruck, Innsbruck, Austria

[15]Department of Pediatrics, Pediatrics III, Medical University of Innsbruck, Innsbruck, Austria

关键词: Headache;    Migraine with aura;    Early vascular ageing;    Pulse-wave velocity;    Carotid intima-media-thickness;    Adolescents;    EVA-Tyrol study;   

DOI  :  10.1186/s12872-023-03409-2

 received in 2023-03-26, accepted in 2023-07-19,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMigraine with aura is associated with an increased risk of cardiovascular disease, yet the pathophysiology is unknown. Suggested underlying mechanisms of aura formation point into the direction of an abnormal vasoreactivity that also extends to the extracranial vasculature.MethodsIn the Early Vascular Ageing Tyrol study, a community-based non-randomized controlled trial conducted in 45 schools and companies in Tyrol (Austria) and South-Tyrol (Italy) between May 2015 and September 2018 aiming to increase cardiovascular health in adolescents, headache syndromes were classified according to the International Classification of Headache Disorders in a face-to-face interview. Carotid-femoral pulse-wave-velocity was measured by applanation tonometry and carotid intima-media-thickness by high-resolution ultrasound of the distal common carotid arteries. Differences in pulse-wave-velocity and carotid intima-media-thickness in youngsters with migraine with aura were compared respectively to those without headache and with other headaches by multivariable linear regression analysis.ResultsOf the 2102 study participants 1589 were aged 14 to 19 (mean 16.8) years and had complete data. 43 (2.7%) reported migraine with aura and 737 (46.4%) other headaches. Mean pulse-wave-velocity was 6.17 m/s (± 0.85) for migraine with aura, 6.06 m/s (± 0.82) for all other headaches and 6.15 (0.95) m/s for participants without headaches. Carotid intima-media-thickness was 411.3 µm (± 43.5) for migraine with aura, 410.9 µm (± 46.0) for all other headaches and 421.6 µm (± 48.4) for participants without headaches. In multivariable linear regression analysis, we found no differences in carotid-femoral pulse-wave-velocity or carotid intima-media-thickness in young subjects with migraine with aura, all other headaches, or no headaches.ConclusionsIn line with previous large-scale studies in adults, we could not demonstrate relevant associations of migraine with aura with markers of arterial stiffness or subclinical atherosclerosis making early vascular ageing an unlikely pathophysiological link between migraine with aura and cardiovascular diseases.Trial registrationFirst registered on ClinicalTrials.gov 29/04/2019 (NCT03929692).

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 4

Fig. 4