The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance

Biomarker Research

Review

Martin Götte¹  Burkhard Greve²  Maria T. Löblein²  Hans Th. Eich²  Mark Sicking²  Fabian M. Troschel²  Isabel Falke² 

[1] Department of Gynecology and Obstetrics, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany;Department of Radiation Oncology, University Hospital Münster, Albert Schweitzer-Campus 1, 48149, Münster, Germany;

关键词: Musashi;    RNA-binding protein;    Stem cells;    Breast cancer;    Endometrial cancer;    Cervical cancer;    Ovarian cancer;    Endometriosis;    Radiotherapy;    Inhibitors;   

DOI  :  10.1186/s40364-023-00516-2

 received in 2023-02-10, accepted in 2023-08-16,  发布年份 2023

来源: Springer

【 摘 要 】

RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate. Mounting evidence suggests that RNA-binding proteins are involved in the onset and progression of multiple malignancies, prompting increasing interest in their potential for therapeutic intervention.The Musashi RNA binding proteins Musashi-1 and Musashi-2 were initially identified as developmental factors of the nervous system but have more recently been found to be ubiquitously expressed in physiological tissues and may be involved in pathological cell behavior. Both proteins are increasingly investigated in cancers given dysregulation in multiple tumor entities, including in female malignancies. Recent data suggest that the Musashi proteins serve as cancer stem cell markers as they contribute to cancer cell proliferation and therapy resistance, prompting efforts to identify mechanisms to target them. However, as the picture remains incomplete, continuous efforts to elucidate their role in different signaling pathways remain ongoing.In this review, we focus on the roles of Musashi proteins in tumors of the female – breast, endometrial, ovarian and cervical cancer – as we aim to summarize current knowledge and discuss future perspectives.

【 授权许可】

CC BY   
© Yumed Inc. and BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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