Dietary Antioxidant Quality Score (DAQS), serum lipids, markers of glucose homeostasis, blood pressure and anthropometric features among apparently metabolically healthy obese adults in two metropolises of Iran (Tabriz and Tehran): a cross-sectional study

BMC Endocrine Disorders

Research

Faria Jafarzadeh¹  Amir Shakarami²  Abnoos Mokhtari Ardekani³  Ayda Zahiri Tousi⁴  Negin Nikrad⁵  Mahdieh Abbasalizad Farhangi⁶ 

[1] Assistant Professor of Endocrinology & Metabolism, Department of Internal Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnourd, Iran;Department of Cardiovascular Medicine, Assistant Professor of Cardiology, Lorestan University of Medical Sciences, Khorramabad, Iran;Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Science, & Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran;Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran;Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Nutrition in Community, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: Dietary antioxidant quality score;    Cardio-metabolic diseases;    Obesity;    Overweight;    Blood pressure;    Metabolic profile;    Glycemic markers;    Metabolic syndrome;   

DOI  :  10.1186/s12902-023-01392-5

 received in 2023-02-16, accepted in 2023-06-27,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundOxidative stress (OS) is associated with a variety of non-communicable diseases, including MetS, diabetes mellitus, metabolic syndrome, and cardiovascular disease through increased production of reactive oxygen species (ROS) and impairment of antioxidant defense mechanisms. Antioxidants can protect cells against free radical damage, so it seems important to determine the relationship between the quality of dietary antioxidants intake and chronic diseases. The Dietary Antioxidant Quality Score (DAQS) is obtained by adding the daily intake of known dietary vitamins and minerals, including selenium, zinc, vitamin A, vitamin C, and vitamin E, compared to the recommended daily intake (RDI). Therefore, this study aims to determine the relationship between DAQS, serum lipids, markers of glucose homeostasis, blood pressure and anthropometric features among obese adults.MethodsIn the present cross-sectional study, 338 individuals who were obese (BMI ≥ 30 kg/m2) aged 20-50 years were recruited from Tabriz and Tehran, Iran. A validated semi-quantitative Food Frequency Questionnaire (FFQ) with 168 food items was used to quantify dietary consumption; accordingly, DAQS was computed. Blood biomarkers were measured using enzyme-linked immunosorbent assay (ELISA) kits. A standard mercury sphygmomanometer was used to assess blood pressure, and bioelectrical impedance analysis (BIA) was performed to determine body composition. The association between the DAQS tertiles and biochemical variables was investigated using multinomial logistic regression.ResultsParticipants in the highest tertile of DAQS have a lower diastolic blood pressure (DBP) values in all of the adjusted models [odds ratio (OR) = 0.920; confidence interval (CI)= 0.852-0.993, P-value = 0.03] in the analysis of co-variance (ANCOVA) model. Similarly, subjects at the second tertile of DAQS had lower DBP compared with the first tertile in age and sex-adjusted model [OR= 0.937; CI= 0.882-0.997]. There was no statistically significant difference for other metabolic parameters in different DAQS tertiles.ConclusionAccording to our findings, higher DAQS was associated with lower DBP among obese adults with obesity in two major cities of Iran (Tehran and Tabriz). Other studies with interventional design are needed to better elucidate these associations and underlying mechanisms.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 2