Neural effects of deep brain stimulation on reward and loss anticipation and food viewing in anorexia nervosa: a pilot study

Journal of Eating Disorders

Research

R. J. T. Mocking¹  P. van den Munckhof¹  D. Denys¹  M. S. Oudijn¹  J. T. W. Linders¹  A. Lok¹  P. R. Schuurman¹  G. A. van Wingen¹  A. A. van Elburg² 

[1] Department of Psychiatry and Neurosurgery, Amsterdam University Medical Centers (AUMC)-Academic Medical Center (AMC), University of Amsterdam (UvA), PO Box 22660, 1100 DD, Amsterdam, The Netherlands;Faculty of Social Sciences, University of Utrecht, Utrecht, The Netherlands;

关键词: Anorexia nervosa;    Deep brain stimulation;    Treatment-refractory;    Body Mass Index;    Neurosurgery;    Clinical trial;    Functional neuroimaging;    Brain networks;    Reward;   

DOI  :  10.1186/s40337-023-00863-3

 received in 2023-04-21, accepted in 2023-08-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAnorexia nervosa (AN) is a severe and life-threatening psychiatric disorder. Initial studies on deep brain stimulation (DBS) in severe, treatment-refractory AN have shown clinical effects. However, the working mechanisms of DBS in AN remain largely unknown. Here, we used a task-based functional MRI approach to understand the pathophysiology of AN.MethodsWe performed functional MRI on four AN patients that participated in a pilot study on the efficacy, safety, and functional effects of DBS targeted at the ventral limb of the capsula interna (vALIC). The patients and six gender-matched healthy controls (HC) were investigated at three different time points. We used an adapted version of the monetary incentive delay task to probe generic reward processing in patients and controls, and a food-specific task in patients only.ResultsAt baseline, no significant differences for reward anticipation were found between AN and HC. Significant group (AN and HC) by time (pre- and post-DBS) interactions were found in the right precuneus, right putamen, right ventral and medial orbitofrontal cortex (mOFC). No significant interactions were found in the food viewing task, neither between the conditions high-calorie and low-calorie food images nor between the different time points. This could possibly be due to the small sample size and the lack of a control group.ConclusionThe results showed a difference in the response of reward-related brain areas post-DBS. This supports the hypotheses that the reward circuitry is involved in the pathogenesis of AN and that DBS affects responsivity of reward-related brain areas.Trial registration Registered in the Netherlands Trial Register (https://www.trialregister.nl/trial/3322): NL3322 (NTR3469).

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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