期刊论文详细信息
AIDS Research and Therapy
HIV infection in adult Ugandans with new-onset type 2 diabetes: exploring its influence on the anthropometric and metabolic profile
Brief Report
Irene Andia-Biraro1  William Lumu2  Davis Kibirige3  Isaac Sekitoleko4  Noela Owarwo5 
[1] Department of Internal Medicine, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda;Department of Medicine, Mengo Hospital, Kampala, Uganda;Department of Medicine, Uganda Martyrs Hospital Lubaga, Kampala, Uganda;Non-communicable Diseases Program, Medical Research Council, Research Unit, Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda, Entebbe, Uganda;Non-communicable Diseases Program, Medical Research Council, Research Unit, Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda, Entebbe, Uganda;The Infectious Diseases Institute, College of Health Sciences, Makerere University Kampala, Kampala, Uganda;
关键词: Anthropometric characteristics;    HIV infection;    Insulin resistance;    Metabolic profile;    Pancreatic beta-cell function;    Sub-Saharan Africa;    Type 2 diabetes;    Uganda;   
DOI  :  10.1186/s12981-023-00553-9
 received in 2023-07-05, accepted in 2023-08-01,  发布年份 2023
来源: Springer
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【 摘 要 】

ObjectiveHIV infection increases the risk of type 2 diabetes and may influence its phenotypic profile. In this study, we aimed to compare the anthropometric and metabolic characteristics of HIV-infected and uninfected adult Ugandans with new-onset type 2 diabetes to evaluate the influence of HIV infection on specific surrogate markers of adiposity, insulin resistance, and pancreatic beta-cell function.MethodsWe consecutively recruited 500 HIV-infected and uninfected adult Ugandans with new-onset type 2 diabetes (diagnosed in < 3 months) from seven tertiary hospitals over a 20-month period and compared their anthropometric and metabolic characteristics to identify any significant differences.ResultsOf the 500 participants with new-onset type 2 diabetes, 59 (11.8%) had a self-reported history of HIV infection. Compared with HIV-uninfected participants with type 2 diabetes, participants with HIV infection and type 2 diabetes had a lower median (IQR) hip circumference (97.8 [91.0-106.0] cm vs. 104.0 [96.0-112.0], p = 0.002) and visceral fat level (8 [6–11] vs. 10 [7–12], p < 0.001) assessed using bioimpedance analysis. No statistically significant difference was noted with the markers of pancreatic beta-cell function (fasting, 30-minute, and 120-minute C-peptide concentrations, oral insulinogenic index, and homeostatic model assessment 2-beta cell function) and insulin resistance (homeostatic model assessment 2-insulin resistance) between both groups.ConclusionIn our study population, HIV infection was not associated with increased adiposity, pancreatic beta-cell function, and insulin resistance. Large prospective studies are needed to investigate the effect of HIV on the pathogenesis of type 2 diabetes in adult Ugandans.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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