Incidence and risk factors of postoperative hyperamylasemia and pancreatitis following total knee arthroplasty: a retrospective study

BMC Musculoskeletal Disorders

Research

Chi Zhang¹  Song Liu¹  Qihao Yang¹  Zhao Wang¹  Wei Hu¹  Fangguo Li² 

[1] Department of Orthopaedic Surgery, The Third Affiliated Hospital of Guangzhou Medical University, 510150, Guangzhou, P. R. China;Department of Orthopaedics, Tianjin Hospital, Tianjin, P. R. China;

关键词: Postoperative hyperamylasemia;    Postoperative pancreatitis;    Complication;    Total knee arthroplasty;   

DOI  :  10.1186/s12891-023-06714-1

 received in 2023-04-21, accepted in 2023-07-12,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPostoperative hyperamylasemia and pancreatitis are recognized complications after abdominal and spinal surgeries. The aim of this study is to investigate the incidence and identify risk factors for postoperative hyperamylasemia and pancreatitis following total knee arthroplasty.Methods170 patients undergoing total knee arthroplasty were retrospectively identified from our database from January 2017 to January 2021. Patients were divided into normal and hyperamylasemia groups based on the presence of serum amylase level within or greater than the normal range. The diagnosis of postoperative pancreatitis was based on the 2012 revised Atlanta Classification of Acute Pancreatitis. Patient demographics, perioperative parameters were investigated with student t test, chi square test and multivariate logistic regression analysis.Results43 patients (25.3%) exhibited postoperative hyperamylasemia while eight patients (4.7%) exhibited serum amylase < 5 times the normal upper limit. One patient (0.6%) was designated as having postoperative pancreatitis. More patients with Hypertriglyceridemia (HTG) were noted in hyperamylasemia group (P = 0.009) compared with normal group. Hyperamylasemia group showed higher preoperative serum amylase (74.95 vs. 55.62 IU/L, P < 0.001), higher intra-operative blood loss (IBL) (117.67 vs. 77.01 mL, P = 0.040) and longer surgical duration (132.98 vs. 107.01 min, P = 0.041). Multivariate logistic analysis revealed that HTG (OR = 0.189, P = 0.006), preoperative serum amylase (OR = 1.042, P < 0.001) and IBL (OR = 1.004, P = 0.022) were independent risk factors for postoperative hyperamylasemia.ConclusionsA significant percentage of patients developed hyperamylasemia after total knee arthroplasty. Patients with HTG, higher preoperative serum amylase and higher IBL had an increased risk of developing postoperative hyperamylasemia and pancreatitis.

【 授权许可】

CC BY   
© The Author(s) 2023

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