Significantly reducing blood loss via a peri-articular injection of tranexamic acid during total knee arthroplasty: a retrospective study

BMC Musculoskeletal Disorders

Shang-Wen Tsai¹  Cheng-Fong Chen¹  Wei-Ming Chen¹  Po-Kuei Wu²  Chao-Ming Chen²  Jesse Chieh-Szu Yang²  Yu-Kuan Lin³ 

[1] Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, 18F, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan, Republic of China;Orthopaedic Department School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, 112, Taipei, Taiwan, Republic of China;Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, 18F, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan, Republic of China;Orthopaedic Department School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, 112, Taipei, Taiwan, Republic of China;Institute of Clinical Medicine, School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, 112, Taipei, Taiwan, Republic of China;Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taoyuan branch, No. 100, Sec. 3, Cheng-Kung Road, 330, Taoyuan, Taiwan, Republic of China;Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, 18F, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan, Republic of China;College of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, 112, Taipei, Taiwan, Republic of China;

关键词: Peri-articular injection;    Tranexamic acid;    Total knee arthroplasty;    Blood loss;    Complication;   

DOI  :  10.1186/s12891-021-04591-0

来源: Springer

【 摘 要 】

BackgroundThe administration of an intra-articular injection (IAI) of tranexamic acid (TXA) has been demonstrated to be effective in reducing both blood loss and transfusion rate during total knee arthroplasty (TKA); however, few studies have reported the efficiency of a peri-articular injection (PAI) of TXA. We studied the efficiency of a PAI of TXA in reducing blood loss during TKA.MethodsFifty patients undergoing primary simultaneous bilateral TKA were enrolled in this retrospective study. The right knee received a PAI of 1 g of TXA (Group I), and the left knee received an IAI of 1 g of TXA (Group II). The clinical outcome measures were a change in blood loss from Hemovac drains and surgical time.ResultsThe decrease in blood loss from the Hemovac was significantly lower in Group I (460.1 ± 36.79 vs. 576.0 ± 34.01, P < 0.001) than in Group II, and no significant difference in surgical times was observed. The blood transfusion rate in the present study was 16 %.ConclusionsA PAI of TXA may reduce blood loss more efficiently than an IAI of TXA during TKA without increased complications such as surgical site infection, poor wound healing, skin necrosis, pulmonary embolism, and deep vein thrombosis.

【 授权许可】

CC BY