Exploring the antibiogram of soil isolates from an indian hospital precinct: link to antibiotic usage

BMC Research Notes

Research Note

Anya E. Shindler¹  Steve Petrovski¹  Colleen J. Thomas²  Ashley E. Franks³  Shalini Kunhikannan⁴  Sumana Kumar⁵  M. N. Sumana⁶  S. Nagarathna⁷ 

[1]Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, 3086, Bundoora, VIC, Australia

[2]Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, 3086, Bundoora, VIC, Australia

[3]Centre for Cardiovascular Biology and Disease Research, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, Australia

[4]Florey Institute of Neuroscience and Mental Health, Pre-clinical Critical Care Unit, University of Melbourne, Melbourne, VIC, Australia

[5]Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, 3086, Bundoora, VIC, Australia

[6]Centre for Future Landscapes, La Trobe University, Bundoora, VIC, Australia

[7]Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, 3086, Bundoora, VIC, Australia

[8]Department of Microbiology, JSS Medical College and Hospital, Mysuru, Karnataka, India

[9]Department of Microbiology, Faculty of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India

[10]Department of Microbiology, JSS Medical College and Hospital, Mysuru, Karnataka, India

[11]Professor and Head, National Institute of Mental Health and Neurosciences, Bangalore, India

关键词: Antibiotic resistance;    Hospitals;    Pseudomonas;    Soil;    Ticarcillin-clavulanic acid;   

DOI  :  10.1186/s13104-023-06450-8

 received in 2023-03-28, accepted in 2023-08-08,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveHospitals serve as hotspots of antibiotic resistance. Despite several studies exploring antibiotic resistance in hospitals, none have explored the resistance profile of soil bacteria from a hospital precinct. This study examined and compared the antibiogram of the soil isolates from a hospital and its affiliated university precinct, to determine if antibiotic resistant bacteria were present closer to the hospital.Results120 soil samples were collected from JSS Hospital and JSS University in Mysore, India across three consecutive seasons (monsoon, winter and summer). 366 isolates were randomly selected from culture. Antibiotic susceptibility testing was performed on 128 isolates of Pseudomonas (n = 73), Acinetobacter (n = 30), Klebsiella species (n = 15) and Escherichia coli (n = 10). Pseudomonas species exhibited the highest antibiotic resistance. Ticarcillin-clavulanic acid, an extended-spectrum carboxypenicillin antibiotic used to treat moderate-to-severe infections, ranked highest amongst the antibiotics to whom these isolates were resistant (n = 51 out of 73, 69.9%). Moreover, 56.8% (n = 29) were from the hospital and 43.1% (n = 22) were from the university precinct, indicating antibiotic resistant bacteria were closer to the hospital setting. This study highlights the effect of antibiotic usage in hospitals and the influence of anthropogenic activities in the hospital on the dissemination of antibiotic resistance into hospital precinct soil.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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