Prevalence of hepatitis B and C viral co-infection and associated factors with HIV infection in children in South Kivu, Democratic Republic of the Congo

BMC Infectious Diseases

Research

Tony Akilimali Shindano¹  Serge Ahuka Miyanga²  Célestin Bisangamo Kyambikwa³  Etienne Mwamba Shindano⁴  Jeff Maotela Kabinda⁵ 

[1] Department of Internal Medicine, Hôpital Provincial Général de Référence de Bukavu (HPGRB), Bukavu, DR, Congo;Faculty of Medicine, Université Catholique de Bukavu (UCB), PB 285, Bukavu, South Kivu, Democratic Republic of the Congo;University of Kindu, Democratic Republic of the Congo, Kindu, Maniema, Democratic Republic of the Congo;Department of Paediatrics, Hôpital Provincial Général de Référence de Bukavu (HPGRB), Bukavu, DR, Congo;Institut Supérieur des Techniques Médicales de Bukavu, Sud Kivu, DR, Congo;University of Kindu, Democratic Republic of the Congo, Kindu, Maniema, Democratic Republic of the Congo;Université Pédagogique Nationale, Kinshasa, DR, Congo;

关键词: HIV;    HBV;    HCV;    Co-infection;    Children;    South Kivu;   

DOI  :  10.1186/s12879-023-08474-8

 received in 2023-02-04, accepted in 2023-07-20,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe World Health Organization’s (WHO) 2030 goal of eradicating Hepatitis B and C viruses must also include HIV co-infected children. However, data on the prevalence of this condition are lacking in the Democratic Republic of Congo (DRC), which is considered as one of the countries with high-prevalence of these viruses. The need to assess the extent of this co-infection in the children of this country is therefore important in order to capitalize on efforts to improve prevention and management of both infections.MethodologyThis is a comparative cross-sectional study conducted from February 04, 2015 to September 03, 2019 at 14 General Reference Hospitals with a pediatric HIV management programme in South Kivu province. The study compared the frequency of hepatitis B (HBV) and C (HCV) markers and factors associated with these two viruses in two equal groups: HIV-positive and HIV-negative children. The data were analyzed using the SPSS version 20.0 software and the significance level was set at p-value less than 0.05.ResultsThe study involved a total of 594 children, 297 of whom were HIV-positive and 297 negative. HBsAg was found in 8.7% of HIV-positive patients and 0.7% for HCV antibodies. On the other hand, among the HIV-negative patients, the proportion of HBsAg was 0.7% but no cases with anti-HCV antibodies were detected. HIV status increases by 14 times the risk of co-occurring with HBV [OR 14.1 (95% CI: 3.33–60.2); p < 0.001] and this risk is not apparent for HCV (p = 0.297). Multivariate logistic regression showed that history of jaundice in the family (aOR:4.19;95% CI: 2.12–11.59), recent hospitalization (aOR:10.7;95% CI: 6.69–17.2), surgery (aOR: 3.24;95% CI: 1.18–8.92), piercing (aOR: 4.26;95% CI: 1.70–10.7) and transfusion in the last 6 months (aOR: 2.69;95% CI: 1.55–4.67) were significantly associated with higher risk of being HBV- HIV co-infected.ConclusionThis study investigated the importance of hepatitis viral co-infections in HIV-positive children in South Kivu. Particular attention should be paid to prevention and early detection of these co-infections in this population.

【 授权许可】

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© BioMed Central Ltd., part of Springer Nature 2023