Oral microbiome homogeneity across diverse human groups from southern Africa: first results from southwestern Angola and Zimbabwe

BMC Microbiology

Research

Magdalena Gayà-Vidal¹  Anne-Maria Fehn¹  Vítor Araújo²  Jorge Rocha²  Admire Phiri³  Jeffrey Wills⁴ 

[1] Centro de Investigação em Biodiversidade e Recursos Genéticos, CIBIO, InBIO Laboratório Associado, Universidade do Porto, Campus de Vairão, 4485-661, Vairão, Portugal;Program in Genomics, Biodiversity and Land Planning, CIBIO, BIOPOLIS, Campus de Vairão, 4485-661, Vairão, Portugal;Centro de Investigação em Biodiversidade e Recursos Genéticos, CIBIO, InBIO Laboratório Associado, Universidade do Porto, Campus de Vairão, 4485-661, Vairão, Portugal;Program in Genomics, Biodiversity and Land Planning, CIBIO, BIOPOLIS, Campus de Vairão, 4485-661, Vairão, Portugal;Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, 4169-007, Porto, Portugal;Department of Linguistics and Language Practice, University of Free State, Bloemfontein, South Africa;University of Zimbabwe, Harare, Zimbabwe;

关键词: Oral microbiota;    Oral microbiome;    Saliva;    Exome sequencing;    Metagenomics;    Socio-economic status;    Subsistence methods;    African populations;   

DOI  :  10.1186/s12866-023-02970-2

 received in 2023-03-31, accepted in 2023-08-04,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundWhile the human oral microbiome is known to play an important role in systemic health, its average composition and diversity patterns are still poorly understood. To gain better insights into the general composition of the microbiome on a global scale, the characterization of microbiomes from a broad range of populations, including non-industrialized societies, is needed. Here, we used the portion of non-human reads obtained through an expanded exome capture sequencing approach to characterize the saliva microbiomes of 52 individuals from eight ethnolinguistically diverse southern African populations from Angola (Kuvale, Kwepe, Himba, Tjimba, Kwisi, Twa, !Xun) and Zimbabwe (Tshwa), including foragers, food-producers, and peripatetic groups (low-status communities who provide services to their dominant neighbors).ResultsOur results indicate that neither host genetics nor livelihood seem to influence the oral microbiome profile, with Neisseria, Streptococcus, Prevotella, Rothia, and Porphyromonas being the five most frequent genera in southern African groups, in line with what has been shown for other human populations. However, we found that some Tshwa and Twa individuals display an enrichment of pathogenic genera from the Enterobacteriaceae family (i.e. Enterobacter, Citrobacter, Salmonella) of the Proteobacteria phylum, probably reflecting deficient sanitation and poor health conditions associated with social marginalization.ConclusionsTaken together, our results suggest that socio-economic status, rather than ethnolinguistic affiliation or subsistence mode, is a key factor in shaping the salivary microbial profiles of human populations in southern Africa.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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