Quantifying ventilation by X-ray velocimetry in healthy adults

Respiratory Research

Research

Andreas Fouras¹  Tamás Ötvös¹  David Wenger¹  Jason P. Kirkness¹  Michael G. Lester²  Bradley W. Richmond³  Kinjal Bhatt Nakrani⁴  Ernesto Gonzalez⁴  Naresh M. Punjabi⁴  Molly Dalzell⁴  Kyle Grealis⁴  Trishul Siddharthan⁴  Alex Tombleson⁴  Darko Stefanovski⁵ 

[1] 4DMedical, Melbourne, Australia;Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA;Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA;Department of Veterans Affairs Medical Center, Nashville, TN, USA;Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA;Division of Pulmonary, Critical Care, and Sleep Medicine, University of Miami, Miami, FL, USA;University of Pennsylvania, Philadelphia, Pennsylvania, USA;

关键词: X-ray velocimetry;    Functional lung imaging;    Ventilation heterogeneity;   

DOI  :  10.1186/s12931-023-02517-z

 received in 2023-04-07, accepted in 2023-08-18,  发布年份 2023

来源: Springer

【 摘 要 】

RationaleX-ray velocimetry (XV) has been utilized in preclinical models to assess lung motion and regional ventilation, though no studies have compared XV-derived physiologic parameters to measures derived through conventional means.ObjectivesTo assess agreement between XV-analysis of fluoroscopic lung images and pitot tube flowmeter measures of ventilation.MethodsXV- and pitot tube-derived ventilatory parameters were compared during tidal breathing and with bilevel-assisted breathing. Levels of agreement were assessed using the Bland-Altman analysis. Mixed models were used to characterize the association between XV- and pitot tube-derived values and optimize XV-derived values for higher ventilatory volumes.Measurements and main resultsTwenty-four healthy volunteers were assessed during tidal breathing and 11 were reassessed with increased minute ventilation with bilevel-assisted breathing. No clinically significant differences were observed between the two methods for respiratory rate (average Δ: 0.58; 95% limits of agreement: -1.55, 2.71) or duty cycle (average Δ: 0.02; 95% limits of agreement: 0.01, 0.03). Tidal volumes and flow rates measured using XV were lower than those measured using the pitot tube flowmeter, particularly at the higher volume ranges with bilevel-assisted breathing. Under these conditions, a mixed-model based adjustment was applied to the XV-derived values of tidal volume and flow rate to obtain closer agreement with the pitot tube-derived values.ConclusionRadiographically obtained measures of ventilation with XV demonstrate a high degree of correlation with parameters of ventilation. If the accuracy of XV were also confirmed for assessing the regional distribution of ventilation, it would provide information that goes beyond the scope of conventional pulmonary function tests or static radiographic assessments.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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