An answered call for aid? Cannabinoid clinical framework for the opioid epidemic

Harm Reduction Journal

Perspective

Krista Hammaker¹  EunBit G. Cho²  David M. Rabin²  Laura Lagano²  Henry Patrick Driscoll²  Steven D. Factor³  Adam S. Howe⁴  Matthew W. Cook⁵  Lawton W. Tang⁶  Rachel Yehuda⁷  Kenneth M. Ford⁸  Belinda Tan⁹  Myro Figura^1,10  Joseph Maroon^1,11  Brian Donohue^1,12  Nathaniel Weathington^1,13  Ben Kelmendi^1,14 

[1] Northeast Ohio Medical University, PO Box 95, 4209 St Rt 44, 44272, Rootstown, OH, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;Abington Neurological Associates, 1151 Old York Rd, Ste 200, 19001, Abington, PA, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;Albany Medical Center, 23 Hackett Blvd, MC-108, 12208, Albany, NY, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;BioReset Medical, 3803 S Bascom Ave, Ste 203, 95008, Campbell, CA, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;Huntington Hospital, 100 West California Blvd, 91105, Pasadena, CA, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, 10029, New York, NY, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;Institute for Human and Machine Cognition (IHMC), 40 South Alcaniz, 32502, Pensacola, FL, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;People Science, Inc, 3870 Del Amo Blvd, Unit 507, 90503, Torrance, CA, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;University of California Los Angeles, 757 Westwood Plaza, Ste 3325, 90095-7403, Los Angeles, CA, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;University of Pittsburgh Medical Center, 1218 Scaife Hall, 3550 Terrace St, 15261, Pittsburgh, PA, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;University of Pittsburgh Medical Center, 1300 Oxford Dr, 15102, Bethel Park, PA, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;University of Pittsburgh Medical Center, 200 Delafield Rd, Ste 2040, 15215, Pittsburgh, PA, USA;The Board of Medicine, 1942 5th Ave, 15219, Pittsburgh, PA, USA;Yale University, 300 George St, Ste 901, 06511, New Haven, CT, USA;

关键词: Cannabinoids;    Chronic pain;    Opioids;   

DOI  :  10.1186/s12954-023-00842-6

 received in 2022-09-13, accepted in 2023-07-24,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe opioid crisis continues in full force, as physicians and caregivers are desperate for resources to help patients with opioid use and chronic pain disorders find safer and more accessible non-opioid tools.Main bodyThe purpose of this article is to review the current state of the opioid epidemic; the shifting picture of cannabinoids; and the research, policy, and current events that make opioid risk reduction an urgent public health challenge. The provided table contains an evidence-based clinical framework for the utilization of cannabinoids to treat patients with chronic pain who are dependent on opioids, seeking alternatives to opioids, and tapering opioids.ConclusionBased on a comprehensive review of the literature and epidemiological evidence to date, cannabinoids stand to be one of the most interesting, safe, and accessible tools available to attenuate the devastation resulting from the misuse and abuse of opioid narcotics. Considering the urgency of the opioid epidemic and broadening of cannabinoid accessibility amidst absent prescribing guidelines, the authors recommend use of this clinical framework in the contexts of both clinical research continuity and patient care.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 3