Transitioning from having no metabolic abnormality nor obesity to metabolic impairment in a cohort of apparently healthy adults

Cardiovascular Diabetology

Research

Roy Eldor¹  Sharon Toker²  David Zeltser³  Hadas Ben-Assayag⁴  Ori Rogowski⁴  Shani Shenhar-Tsarfaty⁴  Shlomo Berliner⁴  Itzhak Shapira⁴  Rafael Y. Brzezinski⁴ 

[1] Affiliated with Sackler Faculty of Medicine, The Tel Aviv University, Tel Aviv, Israel;Diabetes Unit, Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel;Coller School of Management, Tel Aviv University, Tel Aviv, Israel;Department of Emergency Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel;Department of Internal Medicine “C”, “D” & “E”, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239, Tel Aviv, Israel;Affiliated with Sackler Faculty of Medicine, The Tel Aviv University, Tel Aviv, Israel;

关键词: Metabolic syndrome;    Health;    Biomarkers;    Hypertension;    C-reactive protein;    Aging;   

DOI  :  10.1186/s12933-023-01954-w

 received in 2023-06-13, accepted in 2023-08-08,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionThe global prevalence of metabolic syndrome and its association with increased morbidity and mortality has been rigorously studied. However, the true prevalence of “metabolic health”, i.e. individuals without any metabolic abnormalities is not clear. Here, we sought to determine the prevalence of “metabolically healthy” individuals and characterize the “transition phase” from metabolic health to development of dysfunction over a follow-up period of 5 years.MethodsWe included 20,507 individuals from the Tel Aviv Sourasky Medical Center Inflammation Survey (TAMCIS) which comprises apparently healthy individuals attending their annual health survey. A second follow-up visit was documented after 4.8 (± 0.6) years. We defined a group of metabolically healthy participants without metabolic abnormalities nor obesity and compared their characteristics and change in biomarkers over time to participants who developed metabolic impairment on their follow-up visit. The intersections of all metabolic syndrome components and elevated high sensitivity C-reactive protein (hs-CRP) were also analyzed.ResultsA quarter of the cohort (5379 individuals, (26.2%) did not fulfill any metabolic syndrome criteria during their baseline visit. A total of 985 individuals (12.7% of returning participants) developed metabolic criteria over time with hypertension being the most prevalent component to develop among these participants. Individuals that became metabolically impaired over time demonstrated increased overlap between metabolic syndrome criteria and elevated hs-CRP levels. The group that became metabolically impaired over time also presented higher delta values of WBC, RBC, liver biomarkers, and uric acid compared with participants who were consistently metabolically impaired. LDL-C (low-density lipoprotein cholesterol) delta levels were similar.ConclusionsRoughly one-quarter of apparently healthy adults are defined as “metabolically healthy” according to current definitions. The transition from health to metabolic dysfunction is accompanied with active inflammation and several non-metabolic syndrome biomarkers. Aggressive screening for these biomarkers, blood pressure and hs-CRP might help identify apparently healthy individuals at increased risk of developing metabolic syndrome over time.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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