Reduced circulating sTWEAK levels are associated with metabolic syndrome in elderly individuals at high cardiovascular risk

Cardiovascular Diabetology

Original Investigation

Montserrat Fitó¹  Ramón Estruch²  Dolores Corella³  Mònica Bulló⁴  Jordi Salas-Salvadó⁴  Andrés Díaz-López⁴  Javier Díez-Espino⁵  Joan Vendrell⁶  Matilde R Chacón⁶ 

[1] CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain;Cardiovascular Risk and Nutrition Research Group (CARIN), Research Programme in Inflammatory and Cardiovascular Disorders (RICAD), IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain;CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain;Department of Internal Medicine, Hospital Clinic, Institut d’Investigació Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain;Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain;Human Nutrition Unit, Faculty of Medicine and Health Sciences, IISPV, Universitat Rovira i Virgili, C/ Sant Llorenç, 21, Reus, 43201, Tarragona, Spain;CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain;Primary Health Care Centre of Tafalla, Tafalla, Spain;The Biomedical Research Centres Network for Diabetes and Associated Metabolic Disorders (CIBERDEM), University Hospital of Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain;

关键词: sTWEAK;    Metabolic syndrome;    Cardiovascular risk;    Biomarkers;    Insulin resistance;   

DOI  :  10.1186/1475-2840-13-51

 received in 2013-12-04, accepted in 2014-02-20,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe circulating soluble TNF-like weak inducer of apoptosis (sTWEAK) is a cytokine that modulates inflammatory and atherogenic reactions related to cardiometabolic risk. We investigated the association between sTWEAK levels and metabolic syndrome (MetS) and its components in older subjects at high cardiovascular risk.MethodsCross-sectional analysis of 452 non-diabetic individuals (men and women aged 55–80 years) at high cardiovascular risk. MetS was defined by AHA/NHLBI and IDF criteria. Logistic regression analyses were used to estimate odds ratios (ORs) for MetS and its components by tertiles of serum sTWEAK concentrations measured by ELISA.ResultssTWEAK concentrations were lower in subjects with MetS than in those without. In gender- and age-adjusted analyses, subjects in the lowest sTWEAK tertile had higher ORs for overall MetS [1.71 (95% CI, 1.07-2.72)] and its components abdominal obesity [2.01 (1.15-3.52)], hyperglycemia [1.94 (1.20-3.11)], and hypertriglyceridemia [1.73 (1.05-2.82)] than those in the upper tertile. These associations persisted after controlling for family history of diabetes and premature coronary heart disease, lifestyle, kidney function and other MetS components. sTWEAK concentrations decreased as the number of MetS components increased. Individuals in the lowest vs the upper sTWEAK tertile had an increased risk of disclosing greater number of MetS features. Adjusted ORs for individuals with 2 vs ≤1, 3 vs ≤1, and ≥4 vs ≤ 1 MetS components were 2.60 (1.09-6.22), 2.83 (1.16-6.87) and 6.39 (2.42-16.85), respectively.ConclusionIn older subjects at high cardiovascular risk, reduced sTWEAK levels are associated with MetS: abdominal obesity, hypertriglyceridemia and hyperglycemia are the main contributors to this association.

【 授权许可】

Unknown   
© Díaz-López et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.