Effects of gut microbial therapy on lipid profile in individuals with non-alcoholic fatty liver disease: an umbrella meta-analysis study

Systematic Reviews

Systematic Review Update

Amirhossein Naghipour¹  Zahra Momayez Sanat²  Ehsan Amini-Salehi³  Milad Shahdkar⁴  Mahdi Orang Gorabzarmakhi⁴  Iraj Alipourfard⁵  Bahman Fouladi⁶ 

[1] Department of Pharmaceutics, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran;Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran;Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran;Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran;Guilan University of Medical Sciences, Rasht, Iran;Institute of Physical Chemistry, Polish Academy of Sciences, Marsaw, Poland;Pediatric Gastroenterology and Hepatoloy Research center, Zabol University of Medical Sciences, Zabol, Iran;Department of Parasitology and Mycology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran;

关键词: Non-alcoholic fatty liver disease;    Probiotics;    Microbial therapy;    Lipid profile;    Umbrella meta-analysis;    Systematic review;   

DOI  :  10.1186/s13643-023-02299-x

 received in 2023-01-21, accepted in 2023-07-28,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundNon-alcoholic fatty liver disease (NAFLD), the most common liver disease, is closely associated with metabolic conditions such as obesity and diabetes mellitus, which significantly impact human health outcomes. The impaired lipid profiles observed in NAFLD individuals can further contribute to cardiovascular events. Despite the high prevalence of NAFLD, there is currently no confirmed intervention approved for its treatment. This study aimed to summarize the results of meta-analysis studies of randomized control trials assessing the impact of gut microbial therapy (probiotics, synbiotics, and prebiotics) on the lipid profile of individuals with NAFLD.MethodsA systematic search was conducted on PubMed, Scopus, Web of Science, and Cochrane Library up to November 1, 2022. Meta-analyses surveying the impact of microbial therapy on lipid profile parameters (triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and total cholesterol (TC)) in the NAFLD population were included in our umbrella review. The final effect size (ES) was estimated, and sensitivity and subgroup analyses were performed to explore heterogeneity.ResultsFifteen studies were included in this umbrella review. Microbial therapy significantly reduced TG (ES − 0.31, 95% CI − 0.51, − 0.11, P < 0.01), TC (ES − 1.04, 95% CI − 1.46, − 0.61, P < 0.01), and LDL (ES − 0.77, 95% CI − 1.15, − 0.39, P < 0.01) in individuals with NAFLD. However, the effect on HDL was not statistically significant (ES − 0.06; 95% CI − 0.19, 0.07, P = 0.39).ConclusionConsidering the absence of approved treatments for NAFLD and the promising role of microbial therapies in improving the three lipid profiles components in individuals with NAFLD, the use of these agents as alternative treatment options could be recommended. The findings underscore the potential of gut microbial therapy, including probiotics, synbiotics, and prebiotics, in managing NAFLD and its associated metabolic complications.Trial registrationPROSPERO (CRD42022346998).Graphical Abstract

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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