Perspectives on long-acting formulations of pre-exposure prophylaxis (PrEP) among men who have sex with men who are non-adherent to daily oral PrEP in the United States

BMC Public Health

Research

W. C. Goedel¹  K. Curoe²  R. R. Patel²  A. Underwood²  J. Villalobos²  C. Gomillia³  C. Sosnowy⁴  A. Zanowick-Marr⁴  E. Silva⁴  C. Chu⁴  D. Galipeau⁴  Brooke G. Rogers⁵  P. A. Chan⁶  Amy S. Nunn⁶  L. Mena⁷  T. Arnold⁸  C. Sutten-Coats⁹ 

[1] Department of Epidemiology, Brown University School of Public Health, Rhode Island, 02903, Providence, USA;Department of Infectious Diseases, Washington University School of Medicine, 63110, St. Louis, MO, USA;Department of Medicine, Division of Infectious Diseases, University of Mississippi Medical Center, 39216, Jackson, MS, USA;Department of Medicine, Division of Infectious Diseases,, Warren Alpert Medical School of Brown University, 02903, Providence, USA;Department of Medicine, Division of Infectious Diseases,, Warren Alpert Medical School of Brown University, 02903, Providence, USA;Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, 02903, Providence, USA;Department of Medicine, Division of Infectious Diseases,, Warren Alpert Medical School of Brown University, 02903, Providence, USA;Department of Social and Behavioral Sciences, Brown University School of Public Health, Rhode Island, 02903, Providence, USA;Department of Population Health Science, University of Mississippi Medical Center, 39216, Jackson, MS, USA;Department of Medicine, Division of Infectious Diseases, University of Mississippi Medical Center, 39216, Jackson, MS, USA;Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, 02903, Providence, USA;Department of Social and Behavioral Sciences, Brown University School of Public Health, Rhode Island, 02903, Providence, USA;

关键词: HIV prevention;    Pre-exposure prophylaxis (PrEP);    PrEP continuum;    Men who have sex with men (MSM);    Medication adherence;   

DOI  :  10.1186/s12889-023-16382-4

 received in 2022-07-02, accepted in 2023-07-25,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionPre-exposure prophylaxis (PrEP) persistence among men who have sex with men (MSM) in real world clinical settings for HIV prevention is suboptimal. New longer-acting formulations of PrEP are becoming available, including injectables, subdermal implants, and other oral medications. These longer-acting formulations have the potential to improve retention among those who have challenges remaining adherent to daily oral PrEP.MethodsWe interviewed 49 MSM who had initiated but discontinued oral PrEP at three diverse clinics across the United States. We examined participants’ perspectives about long-acting PrEP formulations and how long-acting options could affect PrEP use using thematic analysis.ResultsParticipants were not very knowledgeable about long-acting formulations of PrEP but were open to learning about them and considering use. Participants were concerned about safety and efficacy of products given that they were still newer and/or in development. Finally, participants had clear preferences for oral pills, injectables, and then subdermal implants and were most interested in options that reduced the number of visits to the clinic.ConclusionLong-acting formulations of PrEP are acceptable to MSM with suboptimal PrEP persistence and have the potential to improve PrEP persistence. However, many felt they needed more information on safety, efficacy, and use to consider these options. As these long-acting formulations are implemented, public health campaigns and clinical interventions to encourage may maximize uptake particularly among those who are not currently adherent to daily oral PrEP.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023