Aberrant oscillatory activity in neurofibromatosis type 1: an EEG study of resting state and working memory

Journal of Neurodevelopmental Disorders

Research

Laura J. E. Brown¹  Jonathan Green²  Shruti Garg²  Gorana Pobric³  Samantha J. Booth³  Jason R. Taylor³ 

[1] Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK;Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK;Child & Adolescent Mental Health Services, Royal Manchester Children’s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK;Division of Psychology, Communication and Human Neuroscience, School of Health Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK;

关键词: Electroencephalography (EEG);    Neurofibromatosis type 1 (NF1);    Oscillations;    Oscillatory power;    Phase coherence;    Working memory;   

DOI  :  10.1186/s11689-023-09492-y

 received in 2022-08-25, accepted in 2023-06-30,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundNeurofibromatosis type 1 (NF1) is a genetic neurodevelopmental disorder commonly associated with impaired cognitive function. Despite the well-explored functional roles of neural oscillations in neurotypical populations, only a limited number of studies have investigated oscillatory activity in the NF1 population.MethodsWe compared oscillatory spectral power and theta phase coherence in a paediatric sample with NF1 (N = 16; mean age: 13.03 years; female: n = 7) to an age/sex-matched typically developing control group (N = 16; mean age: 13.34 years; female: n = 7) using electroencephalography measured during rest and during working memory task performance.ResultsRelative to typically developing children, the NF1 group displayed higher resting state slow wave power and a lower peak alpha frequency. Moreover, higher theta power and frontoparietal theta phase coherence were observed in the NF1 group during working memory task performance, but these differences disappeared when controlling for baseline (resting state) activity.ConclusionsOverall, results suggest that NF1 is characterised by aberrant resting state oscillatory activity that may contribute towards the cognitive impairments experienced in this population.Trial registrationClinicalTrials.gov, NCT03310996 (first posted: October 16, 2017).

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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