Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy

BMC Veterinary Research

Case Report

Heather J. Huson¹  John P. Loftus²  Christine Kim³ 

[1]Department of Animal Sciences, Cornell University College of Agriculture and Life Sciences, 201 Morrison Hall, 507 Tower Road, 14853, Ithaca, NY, USA

[2]Department of Clinical Sciences, Cornell University College of Veterinary Medicine, 930 Campus Rd, 14853, Ithaca, NY, USA

[3]IronHorse VetCare, 7660 Amador Valley Blvd E, 94568, Dublin, CA, USA

关键词: Copper-associated hepatopathy;    Alanine aminotransferase;    Chronic hepatopathy;    Canine;    Genetics;   

DOI  :  10.1186/s12917-023-03681-6

 received in 2022-11-28, accepted in 2023-07-28,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAlanine aminotransferase (ALT) is commonly used as a marker of hepatocellular injury. Increased serum ALT activity due to hepatocyte injury occurs in copper-associated hepatopathy (CuCH) and other necroinflammatory liver conditions. Blood ALT concentrations are frequently used to monitor therapy in cases of CuCH. Low serum ALT activities have been associated with an allele at a CFA13 locus.Case presentationA 9-year-old female spayed Siberian Husky was diagnosed with CuCH (hepatic copper dry weight 2680 µg/g [normal, 120–400 µg/g; toxic, > 1500 µg/g]) and a normal ALT (78 U/L; reference range, 10–125 U/L). Mild hepatocellular necrosis was evident histologically. Genetic testing (Embark) revealed that the dog was heterozygous for the low ALT activity gene allele.ConclusionsThis case report illustrates the clinical implications for diagnosing and managing necroinflammatory liver disease such as CuCH in dogs with a low ALT activity genotype.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023