Comparing pharmaceutical persistence across terrestrial and aquatic environments: do studies according to OECD 307 and OECD 308 lead to similar outcomes?

Environmental Sciences Europe

Research

Ute Brandt¹  Silvia Berkner¹ 

[1]German Environment Agency, Unit IV2.2 Pharmaceuticals, Wörlitzer Platz 1, 06844, Dessau-Rosslau, Germany

关键词: Pharmaceuticals;    Persistence;    Transformation;    OECD 307;    OECD 308;   

DOI  :  10.1186/s12302-023-00783-8

 received in 2023-04-13, accepted in 2023-08-14,  发布年份 2023

来源: Springer

【 摘 要 】

Information on transformation and persistence of chemical substances in the environment is important for hazard and risk assessment within a regulatory context or as a decision criterion in a safe and sustainable by design framework. Half-lives for human and veterinary medicinal products available from marketing authorization applications were compared between soil (OECD 307) and aquatic water/sediment systems (OECD 308). The comparison shows, that there is no obvious correlation between the total system half-lives in the two different compartments and that surpassing persistence criteria is compartment-specific in 45% of the cases.

【 授权许可】

CC BY   
© Springer-Verlag GmbH Germany, part of Springer Nature 2023

【 图 表 】

Fig. 1