Investigation of the interaction between Genetic Risk Score (GRS) and fatty acid quality indices on mental health among overweight and obese women

BMC Women's Health

Research

Mahsa Samadi¹  Fatemeh Gholami¹  Khadijeh Mirzaei²  Niloufar Rasaei³  Seyedeh Fatemeh Fatemi⁴  Alireza Khadem⁵ 

[1] Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran;Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran;Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran;Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran;Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific Education and Research Network (USERN), Tehran, Iran;Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran;

关键词: Genetic risk score;    Dietary fat quality indices;    Mental health;    Overweight;    Obese;   

DOI  :  10.1186/s12905-023-02491-0

 received in 2022-09-15, accepted in 2023-06-19,  发布年份 2023

来源: Springer

【 摘 要 】

Background & aimsMental disorders are associated with dietary fatty acids and genome-wide association studies have found multiple risk loci robustly related to depression, anxiety, and stress. The aim of this study is to investigate the interaction of genetic risk score (GRS) and dietary fat quality indices on mental health.MethodsThis cross-sectional study included 279 overweight and obese women for N6/N3 ratio and 378 overweight and obese women for CSI aged 18–68 years. Using reliable and verified standard protocols, body composition, anthropometric indices, blood pressure, physical activity, and dietary fat quality were measured. Serum samples were used to determine biochemical tests. A genetic risk score (GRS) was calculated using the risk alleles of the three SNPs. A generalized linear model (GLM) was applied to assess the interactions between GRS and fat quality indices. Mental health was evaluated using Depression Anxiety Stress Scales (DASS-21).ResultsThe mean (± SD) age and BMI of our participants were 36.48 (8.45) and 30.73 (3.72) kg/m2 respectively. There was a marginally significant mean difference among tertiles of the CSI in terms of stress (P = 0.051), DASS-21 (P = 0.078) in the crude model. After adjusting for age, energy intake, physical activity and BMI in model 1, there was a positive interaction between GRS and T3 of N6/N3 ratio on anxiety (β = 0.91, CI = 0.08,1.75, P = 0.031), depression (β = 1.05, CI = 0.06,2.04, P = 0.037), DASS-21 (β = 2.22, CI= -0.31,4.75, P = 0.086).ConclusionOur findings indicate that higher ratio of N-6 to N-3 considering genetics were predictive of mental disorder in our population.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023