A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers

Journal of Nanobiotechnology

Research

Xiaocui Wu¹  Yao Li¹  Junfei Yang¹  Zhenzhong Zhang²  Yun Zhang²  Lei Wang²  Qianhua Feng²  Qingling Song²  Hongjuan Zhao² 

[1] School of Pharmaceutical Sciences, Zhengzhou University, 450001, Zhengzhou, People’s Republic of China;Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, 450001, Zhengzhou, People’s Republic of China;School of Pharmaceutical Sciences, Zhengzhou University, 450001, Zhengzhou, People’s Republic of China;Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, 450001, Zhengzhou, People’s Republic of China;Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, 450001, Zhengzhou, People’s Republic of China;

关键词: Biomimetic spore;    Oral drug delivery;    Spore capsid;    Biological barrier;   

DOI  :  10.1186/s12951-023-01995-z

 received in 2023-01-18, accepted in 2023-07-10,  发布年份 2023

来源: Springer

【 摘 要 】

The biological barriers have seriously restricted the efficacious responses of oral delivery system in diseases treatment. Utilizing a carrier based on the single construction means is hard to overcome these obstacles simultaneously because the complex gastrointestinal tract environment requires carrier to have different or even contradictory properties. Interestingly, spore capsid (SC) integrates many unique biological characteristics, such as high resistance, good stability etc. This fact offers a boundless source of inspiration for the construction of multi-functional oral nanoplatform based on SC without further modification. Herein, we develop a type of biomimetic spore nanoplatform (SC@DS NPs) to successively overcome oral biological barriers. Firstly, doxorubicin (DOX) and sorafenib (SOR) are self-assembled to form carrier-free nanoparticles (DS NPs). Subsequently, SC is effectively separated from probiotic spores and served as a functional vehicle for delivering DS NPs. As expect, SC@DS NPs can efficaciously pass through the rugged stomach environment after oral administration and further be transported to the intestine. Surprisingly, we find that SC@DS NPs exhibit a significant improvement in the aspects of mucus penetration and transepithelial transport, which is related to the protein species of SC. This study demonstrates that SC@DS NPs can efficiently overcome multiple biological barriers and improve the therapeutic effect.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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