The effect of conjugated linoleic acids on inflammation, oxidative stress, body composition and physical performance: a comprehensive review of putative molecular mechanisms

Nutrition & Metabolism

Review

Andrés Alexis Ramírez-Coronel¹  Mohammed Nader Shalaby²  Mahsa Malekahmadi³  Pegah Rahimi⁴  Walid Kamal Abdelbasset⁵  Zachary S. Clayton⁶  Husna Dharma Putera⁷  Saidmurodkhon S. Murtazaev⁸  Rumi Iqbal Doewes⁹  Naseh Pahlavani^1,10  Abduladheem Turki Jalil^1,11  Elyas Nattagh-Eshtivani^1,12 

[1] Azogues Campus Nursing Career, Health and Behavior Research Group (HBR), Psychometry and Ethology Laboratory, Catholic University of Cuenca, Azogues, Ecuador;Biological Sciences and Sports Health Department, Faculty of Physical Education, Suez Canal University, Ismailia, Egypt;Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran;Department of Clinical Pharmacy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran;Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia;Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt;Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA;Department of Surgery, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia;Department of Therapeutic Pediatric Dentistry, Dean of the Faculty of International Education, Tashkent State Dental Institute, Tashkent, Uzbekistan;Department of Scientific Affairs, Samarkand State Medical University, Amir Temur Street 18, Samarkand, Uzbekistan;Faculty of Sport, Universitas Sebelas Maret, Jl. Ir. Sutami, 36A, Kentingan, Surakarta, Indonesia;Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat-e Heydariyeh, Iran;Medical Laboratories Techniques Department, Al-Mustaqbal University College, 51001, Hilla, Babylon, Iraq;Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran;

关键词: Conjugated linoleic acid;    Inflammation;    Oxidative stress;    Body composition;    Physical Performance;   

DOI  :  10.1186/s12986-023-00758-9

 received in 2023-02-08, accepted in 2023-08-25,  发布年份 2023

来源: Springer

【 摘 要 】

Conjugated linoleic acids (CLAs) are polyunsaturated fatty acids primarily found in dairy products and ruminant animal products such as beef, lamb, and butter. Supplementation of CLAs has recently become popular among athletes due to the variety of health-promoting effects, including improvements in physical performance. Preclinical and some clinical studies have shown that CLAs can reduce inflammation and oxidative stress and favorably modulate body composition and physical performance; however, the results of previously published clinical trials are mixed. Here, we performed a comprehensive review of previously published clinical trials that assessed the role of CLAs in modulating inflammation, oxidative stress, body composition, and select indices of physical performance, emphasizing the molecular mechanisms governing these changes. The findings of our review demonstrate that the effect of supplementation with CLAs on inflammation and oxidative stress is controversial, but this supplement can decrease body fat mass and increase physical performance. Future well-designed randomized clinical trials are warranted to determine the effectiveness of (1) specific doses of CLAs; (2) different dosing durations of CLAs; (3) various CLA isomers, and the exact molecular mechanisms by which CLAs positively influence oxidative stress, inflammation, body composition, and physical performance.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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