The IBER study: a feasibility randomised controlled trial of imagery based emotion regulation for the treatment of anxiety in bipolar disorder

International Journal of Bipolar Disorders

Research

Judit Simon¹  Emily A. Holmes²  Jemma Regan³  Rod S. Taylor⁴  Susie A. Hales⁵  Craig Steel⁶  Nicola Morant⁷  Michael Brown⁸  Lynette Meredith⁹  Kim Wright^1,10  Guy M. Goodwin^1,11  Susie Jennings^1,12  Michaela Sibsey^1,12  Zoe Thomas^1,13 

[1] Department of Health Economics, Center for Public Health, Medical University of Vienna, Vienna, Austria;Department of Psychiatry, University of Oxford, Oxford, UK;Department of Psychology, Uppsala University, Uppsala, Sweden;Devon Partnership NHS Trust, Devon, UK;MRC/CSO Social and Public Health Sciences Unit and Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK;Oxford Health NHS Foundation Trust and University of Oxford, Oxford, UK;Oxford Health NHS Foundation Trust and University of Oxford, Oxford, UK;University of Oxford, Oxford, UK;University College London, London, UK;University of Cambridge, Cambridge, UK;University of East London, London, UK;University of Exeter, EX4 4PY, Exeter, UK;University of Oxford, Oxford, UK;University of Reading, Reading, UK;University of Surrey, Surrey, UK;

关键词: Bipolar disorder;    Anxiety;    Emotion regulation;    Mental imagery;    Psychological intervention;    Feasibility;   

DOI  :  10.1186/s40345-023-00305-8

 received in 2022-10-31, accepted in 2023-06-26,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundIntrusive mental imagery is associated with anxiety and mood instability within bipolar disorder and therefore represents a novel treatment target. Imagery Based Emotion Regulation (IBER) is a brief structured psychological intervention developed to enable people to use the skills required to regulate the emotional impact of these images.MethodsParticipants aged 18 and over with a diagnosis of bipolar disorder and at least a mild level of anxiety were randomly assigned (1:1) to receive IBER plus treatment as usual (IBER + TAU) or treatment as usual alone (TAU). IBER was delivered in up to 12 sessions overs 16 weeks. Clinical and health economic data were collected at baseline, end of treatment and 16-weeks follow-up. Objectives were to inform the recruitment process, timeline and sample size estimate for a definitive trial and to refine trial procedures. We also explored the impact on participant outcomes of anxiety, depression, mania, and mood stability at 16-weeks and 32-weeks follow-up.ResultsFifty-seven (28: IBER + TAU, 27: TAU) participants from two sites were randomised, with 50 being recruited within the first 12 months. Forty-seven (82%) participants provided outcome data at 16 and 32-weeks follow-up. Thirty-five participants engaged in daily mood monitoring at the 32-week follow-up stage. Retention in IBER treatment was high with 27 (96%) attending ≥ 7 sessions. No study participants experienced a serious adverse event.DiscussionThe feasibility criteria of recruitment, outcome completion, and intervention retention were broadly achieved, indicating that imagery-focused interventions for bipolar disorder are worthy of further investigation.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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