Network-level functional topological changes after mindfulness-based cognitive therapy in mood dysregulated adolescents at familial risk for bipolar disorder: a pilot study

BMC Psychiatry

Sian Cotton¹  Maxwell J. Tallman²  Thomas J. Blom²  Kaitlyn M. Bruns²  Luis Rodrigo Patino Duran²  Melissa P. DelBello²  Du Lei²  Jing Yang³  Kun Qin³  Wenbin Li⁴  John A. Sweeney⁴  Qiyong Gong⁵ 

[1] Department of Family and Community Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA;Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA;Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China;Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China;Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA;Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China;Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China;Functional and Molecular Imaging Key Laboratory of Sichuan Province, Chengdu, China;

关键词: Resting-state functional magnetic resonance imaging;    Graph theory;    Emotion regulation;    Psychoradiology;    Bipolar disorder;    Familial risk;    Mindfulness-based intervention;   

DOI  :  10.1186/s12888-021-03211-4

来源: Springer

【 摘 要 】

BackgroundGiven that psychopharmacological approaches routinely used to treat mood-related problems may result in adverse outcomes in mood dysregulated adolescents at familial risk for bipolar disorder (BD), Mindfulness-Based Cognitive Therapy for Children (MBCT-C) provides an alternative effective and safe option. However, little is known about the brain mechanisms of beneficial outcomes from this intervention. Herein, we aimed to investigate the network-level neurofunctional effects of MBCT-C in mood dysregulated adolescents.MethodsTen mood dysregulated adolescents at familial risk for BD underwent a 12-week MBCT-C intervention. Resting-state functional magnetic resonance imaging (fMRI) was performed prior to and following MBCT-C. Topological metrics of three intrinsic functional networks (default mode network (DMN), fronto-parietal network (FPN) and cingulo-opercular network (CON)) were investigated respectively using graph theory analysis.ResultsFollowing MBCT-C, mood dysregulated adolescents showed increased global efficiency and decreased characteristic path length within both CON and FPN. Enhanced functional connectivity strength of frontal and limbic areas were identified within the DMN and CON. Moreover, change in characteristic path length within the CON was suggested to be significantly related to change in the Emotion Regulation Checklist score.Conclusions12-week MBCT-C treatment in mood dysregulated adolescents at familial risk for BD yield network-level neurofunctional effects within the FPN and CON, suggesting enhanced functional integration of the dual-network. Decreased characteristic path length of the CON may be associated with the improvement of emotion regulation following mindfulness training. However, current findings derived from small sample size should be interpreted with caution. Future randomized controlled trials including larger samples are critical to validate our findings.

【 授权许可】

CC BY