Optical coherence tomography angiography biomarkers in a bi-monthly maintenance dosing aflibercept in patients with neovascular age-related macular degeneration

BMC Ophthalmology

Research

Min Seok Kang¹  Eung Suk Kim¹  Jong Beom Park¹  Kiyoung Kim¹  Seung-Young Yu¹ 

[1] Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University, 23, Kyungheedae-ro,, 02447, Dongdaemun-gu, Seoul, Republic of Korea;

关键词: Age-related macular degeneration (AMD/ARMD);    Optical coherence tomography angiography (OCTA);    Swept-source optical coherence tomography angiography (SS-OCTA);    Aflibercept;    Macular neovascularization;    Vessel density;    Vessel length density;   

DOI  :  10.1186/s12886-023-03039-4

 received in 2023-03-07, accepted in 2023-06-12,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeTo evaluate the correlations between swept-source optical coherence tomography angiography (SS-OCTA) parameters and clinical outcomes in eyes with neovascular age-related macular degeneration (nAMD) administered a bimonthly intravitreal aflibercept regimen.MethodsThis prospective, single-arm, interventional study enrolled 33 patients with treatment-naïve nAMD. The eyes received three monthly aflibercept injections followed by five bi-monthly regimens (total 50 weeks). The structural parameters including central subfield thickness (CST) and 5 mm pigment epithelial detachment (PED) volume and microvascular parameters including macular neovascularization (MNV) area, vessel density (VD), and vessel length density (VLD) were recorded every before and 1 week after treatment.ResultsPatients who gained > 5 letters of best-corrected visual acuity (BCVA) from the baseline showed greater decreases in VD and VLD during the loading phase. Patients without recurrent or persistent fluid during the maintenance phase showed greater decreases in CST and 5 mm PED volume after the first injection. The decrease in mean VD during the loading phase was significantly correlated with the final BCVA (r = -0.820, p = 0.004). Moreover, the decrease in mean VLD during the loading phase was significantly correlated with the improvement in the final BCVA (r = -0.726, p = 0.017).ConclusionsThe decrease in mean VD during the loading phase was significantly negatively correlated with the final BCVA at the last visit. The decrease in mean VLD during the loading phase, mean CST during the loading phase, and the improvement in final BCVA showed significant correlations. Therefore, early changes in OCTA microvascular and OCT structural parameters could help predict clinical outcomes in nAMD.Trial RegistrationThe trial was registered with the Clinical Research Information Service (CRIS), which joined the WHO International Clinical Trials Registry Platform (ICTRP) (Registration number: KCT0007375, Date of first trial registration: 10/06/2022).

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2023_38_Article_IEq42.gif

41116_2023_38_Article_IEq39.gif

41116_2023_38_Article_IEq12.gif