TERC haploid cell reprogramming: a novel therapeutic strategy for aplastic anemia

Molecular Medicine

Review

Siyuan Cui¹  Yan Wang¹  Ruirong Xu¹  Xinyu Tang²  Kaiqing Chen² 

[1] Department of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, 250014, Jinan, China;Institute of Hematology, Shandong University of Traditional Chinese Medicine, 250014, Jinan, China;Shandong Provincial Health Commission Key Laboratory of Hematology of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, 250014, Jinan, China;Shandong University of Traditional Chinese Medicine, 250014, Jinan, China;

关键词: Telomerase RNA component;    Cell reprogramming;    Aplastic anemia;    Telomerase;   

DOI  :  10.1186/s10020-023-00691-w

 received in 2023-03-21, accepted in 2023-06-22,  发布年份 2023

来源: Springer

【 摘 要 】

The telomerase RNA component (TERC) gene plays an important role in telomerase-dependent extension and maintenance of the telomeres. In the event of TERC haploinsufficiency, telomere length is often affected; this, in turn, can result in the development of progeria-related diseases such as aplastic anemia (AA) and congenital keratosis. Cell reprogramming can reverse the differentiation process and can, therefore, transform cells into pluripotent stem cells with stronger differentiation and self-renewal abilities; further, cell reprograming can also extend the telomere length of these cells, which may be crucial in the diagnosis and treatment of telomere depletion diseases such as AA. In this study, we summarized the effects of TERC haploid cell reprogramming on telomere length and the correlation between this alteration and the pathogenesis of AA; by investigating the role of cell reprogramming in AA, we aimed to identify novel diagnostic indicators and therapeutic strategies for patients with AA.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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