The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target

Cancer Cell International

Review

Souzan Najafi¹  Ahad Mokhtarzadeh¹  Maryam Tohidast¹  Mohammad Amini¹  Seyedeh Zahra Bahojb Mahdavi¹  Pouriya Sameti¹ 

[1] Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: MicroRNA-182;    Cancer;    Signaling pathways;   

DOI  :  10.1186/s12935-023-02972-0

 received in 2023-02-28, accepted in 2023-06-13,  发布年份 2023

来源: Springer

【 摘 要 】

A wide range of studies have indicated that microRNAs (miRNAs), a type of small single-stranded regulatory RNAs, are dysregulated in a different variety of human cancers. Therefore, they are expected to play important roles in tumorigenesis by functioning as oncogenic (oncomiRs) or tumor-suppressive miRNAs. Subsequently, their potential as diagnostic and therapeutic targets for malignancies has attracted attention in recent years. In particular, studies have revealed the aberrant expression of miR-182 through tumorigenesis and its important roles in various aspects of malignancies, including proliferation, metastasis, and chemoresistance. Accumulating reports have illustrated that miR-182, as a dual-role regulator, directly or indirectly regulates the expression of a wide range of genes and modulates the activity of various signaling pathways involved in tumor progression, such as JAK / STAT3, Wnt / β-catenin, TGF-β, and P13K / AKT. Therefore, considering the high therapeutic and diagnostic potential of miR-182, this review aims to point out the effects of miR-182 dysregulation on the signaling pathways involved in tumorigenesis.

【 授权许可】

CC BY   
© The Author(s) 2023

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Fig. 1

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